The Co(II) atom in the title compound, [Co(C(8)H(5)NO(4))(C(12)H(8)N(2))(H(2)O)(3)]·3H(2)O, is six-coordinated in a CoN(3)O(3) octa-hedral geometry; the water-coordinated Co(II) atom is chelated by the N-heterocycle. An inter-molecular N-H⋯O hydrogen bond occurs. The carboxyl-ate entity coordinates through the amino group. The carboxyl-ate donor unit, coordinated and uncoordinated water mol-ecu...

The title compound, (C(13)H(11)N(2))(2)[Ni(C(7)H(3)NO(4))(2)]·3H(2)O, consists of a mononuclear anionic complex, two 9-amino-acridinium cations and three uncoordinated water mol-ecules. Two pyridine-2,6-dicarboxyl-ate (pydc) ligands are bound to the Ni(II) ion, giving an NiN(2)O(4) bonded set. The coordination geometry around the Ni(II) atom is distorted octa-hedral. There are two types of robu...

In the title compound, C11H11N3O3S·3H2O, the non-H atoms of the main mol-ecule are approximately planar, with an r.m.s. deviation of 0.030 Å. There is a bifurcated intra-molecular N-H⋯(O,S) hydrogen bond present forming S(6) and S(5) ring motifs. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link the molecules into a three-dimensional network.

In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated the methylene chloride/methanol extract heartwood. They tested for in vitro protective effect against chromosome aberrations peripheral human lymphocytes, using cytokinesis-block micronucleus assay. All compounds (in minimal doses 1 μg/mL) exerted a beneficial by decreasing DNA damage lymphoc...

In the title compound, 2C(6)H(9)N(2) (+)·C(5)H(2)N(2)O(4) (2-)·3H(2)O, the 1H-pyrazole-3,5-dicarboxyl-ate anion is close to planar [maximum deviation = 0.208 (1) Å]. The two distinct 2-amino-5-methyl-pyridinium cations are also almost planar, with maximum deviations of 0.018 (2) and 0.014 (2) Å. In the crystal, pairs of inter-molecular N-H⋯O and O-H⋯O hydrogen bonds connect neighbouring mol-ecu...

PURPOSE: An aggressive trimodality approach from the Minnie Pearl Cancer Research Network [carboplatin AUC = 6, days 1 and 22; 5-fluorouracil 225 mg/m2 continuous infusion, days 1-42, paclitaxel 200 mg/m2, days 1 and 22; 45 Gy] has resulted in remarkable pathologic response rates but notable toxicity. This trial was designed to mitigate this toxicity by starting with a lower carboplatin dose, A...

background:  hydrogen has been demonstrated can selectively reduce the hydroxyl, which is the main cause of ionizing radiation-induced damage. amifostine (am) is the only radioprotective drug approved by the u.s. food and drug administration for use in radiotherapy. the purpose of the present study was to investigate the combined radio-protective effect of hydrogen rich water (hrw) and am. mate...