The effects of antiepileptic drugs, gabapentin, pregabalin and vigabatrin, on brain gamma-aminobutyric acid (GABA), glutamate and glutamine concentrations were studied in Long Evans rats using proton magnetic resonance spectroscopy (MRS) of perchloric acid extracts. Cellular glutamate concentrations significantly decreased by 7% (P<0.05) 2 hours after intraperitoneal injection of 100mg/kg gabap...

The principal sites of gamma-aminobutyric acid (GABA) uptake in lobster nerve-muscle preparations have been determined with radioautographic techniques after binding of the amino acid to proteins by aldehyde fixation. Semiquantitative studies showed that about 30% of the radioactive GABA taken into the tissue was bound to protein by fixation. Both light and electron micrographs showed dense acc...

Leaf senescence is highly regulated and complex developmental process that involves degradation of macromolecules as well as its recycling. Senescence process involves loss of chlorophyll, degradation of proteins, nucleic acid, lipid and mobilization of nutrients through its transport to the growing parts, developing fruits and seeds. Nitrogen is the most important nutrient to be recycled in se...

Abstract Pain is a complex physiological and psychological activity, involving at least three dimensions, including pain sensation, emotion, cognition. Acupuncture can clearly relieve the sensation of patients improve emotion cognition induced by pain; acupuncture participates in multi-dimensional regulation through brain regions limbic system such as anterior cingulate cortex (ACC), amygdala (...

IN THE TWO PRECEDING PAPERS it was reported that gamma-aminobutyric acid (GABA) was the most active of ten blocking substances extracted from the nervous systems of lobsters and crabs. The concentrations of GABA in several peripheral nerves were measured and found to be highest in a nerve that contained only one motor and one inhibitory axon. It was natural to wonder if GABA was specifically co...

γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that is found in uni- and multi-cellular organisms and is involved in many aspects of plant life cycle. GABA metabolism occurs by the action of evolutionary conserved enzymes that constitute the GABA shunt, bypassing two steps of the TCA cycle. The central position of GABA in the interface between plant carbon and nitrogen metabolism ...