Associations between the presence of a constitutional variant of delta-aminolevulinic acid dehydratase (ALAD-2) and lead concentrations in blood and bone, as well as between this allele and indices of kidney function, were investigated among 691 members of a construction trade union. The average blood lead level in this group was 7.78 micrograms/dl. No significant difference was observed in blo...

It is well know that exposure to lead causes disorders of porphyrin metabolism such as elevation of ƒÂ-aminolevulinic acid (ALA) and coproporphyrin (CP) in urine, accumulation of protoporphyrin (PROTO) in erythrocytes, and inhibition of erythrocyte ƒÂ-aminolevulinic acid dehydratase (ALAD) activity.') In addition, it has been reported that inorganic tin (II) also inhibits erythrocyte ALAD activ...

This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were assessed using data obtained from a specially designed Questionnaire for lead exposure and toxic effects assessment, physical examination, spirometry, ECG, and laboratory tests including blood lead level (BLL) and biomarkers of lead toxic eff...

We examined six newly identified polymorphisms in the delta-aminolevulinic acid dehydratase (ALAD) single-nucleotide polymorphisms (SNPs) to determine if these SNPs could modify the relationship between blood lead (PbB) and some renal parameters. This is a cross-sectional study of 276 lead-exposed workers in Vietnam. All workers were measured for PbB, urinary retinol-binding protein (URBP), uri...