A dianionic Ireland-Claisen rearrangement of chiral, nonracemic α-methyl-β-hydroxy allylic esters has been developed that proceeds with high diastereoselectivity and provides products containing three contiguous stereogenic carbons, including a quaternary center. The potential utility of the rearrangement for complex molecule synthesis is also demonstrated.

Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in primary rabbit kidney and human skin fibrolast cells.

Shedlovsky's results,16 which differ from all others. There can be no doubt that most if not all, of these minima are spurious. One observation, which we have made may have an important bearing on this problem. In many cases, on addition of the first sample, the resistance of the solution drifted to lower values. The rate of this drift depended on the salt as well. as on the sample. In some ins...

A silicogermanate, PKU-12, with the -CLO type of zeolite framework was hydrothermally synthesized under fluoride media using diisopropylethylmethylammonium as a structure directing agent. The formation of the silicogermanate zeolite with 20-ring channels has not only extended the -CLO family from phosphates into silicogermanates, but also demonstrated its structural diversity.

A novel two-dimensional NMR pulse sequence, H2BC, for long-range correlation of 1H and 13C nuclei is presented. The experiment has several attractive features compared to the widely used HMBC experiment, for example, (a) typically strong enhancement of correlations over two bonds while suppressing those over more bonds, that is, resolving ambiguities in standard HMBC spectra and showing two-bon...

Animals dosed orally with nitrite (1.5 X 10(-3) mol/kg) and nonyl dimethylbenzylammonium bromide (2.9 X 10(-4) mol/kg) exhibit liver damage within two hours; cetyl trimethylammonium bromide plus nitrite was not significantly hepatotoxic. Both nonyl dimethylbenzyl ammonium bromide and cetyl trimethylammonium bromide were demethylated by rat-liver microsomal preparations; substrate concentrations...

The current awareness of problems concerned with drug resistant strains of Staphylococcus and other bacteria includes an interest in the role of bedding, nightclothing, and other garments as means of transmission of these bacteria. Duguid and Wallace (1948), Ridenour (1950), Church and Loosli (1953), Blowers and Wallace (1955), and Ravenholt and La Veck (1956) are among those who have reported ...

The germicidal potency of quatemary ammonium compounds is known to depend mainly on the chemical structure of the cation, the nature of the anion having little if any effect (Glassman, 1948). The relation of structure of the cation to bactericidal activity has been studied extensively insofar as chain length of the hydrophobic or hydrocarbon group is concerned. In compounds with only one long c...

We evaluated the efficacy of the antimicrobial activity of cotton-polyester fabric treated with 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride (DC 5700), a quaternary ammonium compound bound irreversibly to the material. Significant antimicrobial activity was observed with 58 of 61 gram-positive cocci but with only 1 of 35 gram-negative bacilli and 0 of 5 yeasts. No inhibition of ...

The progress of antimicrobial therapy contributes to the development of strains of fungi resistant to antimicrobial drugs. Since cationic surfactants have been described as good antifungals, we present a SAR study of a novel homologous series of 140 bis-quaternary imidazolium chlorides and analyze them with respect to their biological activity against Candida albicans as one of the major opport...