Cetuximab (Erbitux) is an antiepidermal growth factor receptor (EGFR) monoclonal antibody that has been shown to delay the progression of metastatic colorectal cancer. The cutaneous side effects of cetuximab resulting from its effects on normal epidermal cells are well established. Periocular side effects, including blepharitis, trichomegaly, dry eye and conjunctivitis, have also been reported....

The purpose of this study is to analyze clinical experience about the effects of human amniotic membrane transplantation in eyes with neurotrophic ulcers. In 11 eyes the application of amniotic membrane was performed since January 1999 because of neurotrophic ulcers. The follow up period was longer than 12 months: 19.7+/-6.0 months. The average healing period after the surgery was 1.6+/-0.6 wee...

Purpose:Human amniotic fluid contains several growth factors and hyaluronic acid. It has positive effect in healing the tendon, nerve bone injuries. Human membrane effects on is also used for skin burns complex wounds. We hypothesized that human have stimulating fracture healing. The aim of this study to investigate rat tibial model.

M. Parthasarathy, R. Sasikala, P. Gunasekaran and J. Raja Dept. of Biotechnology, Vel Sri Ranga Sanku College of Arts and Science, Avadi, Chennai-62 Dept. of Biological Control, King Institute of Preventive Medicine and Research, Guindy, Chennai-32, India [email protected]*; +91 9677299256 ______________________________________________________________________________________________ Abstrac...

Vertical root fracture(VRF) is one of the common reasons for extraction of endodontically treated teeth. Though many options of saving such teeth were available, they were not of much success. Therefore the objective of this article is to discuss one such case. A 50 year old male patient reported with Vertical root fracture and 15 mm of periodontal probing depth in the distal aspect of 14. Radi...

Ophthalmol. 1998;116:372-373. 22. Tseng SC, Prabhasawat P, Lee SH. Amniotic membrane transplantation for conjunctival surface reconstruction. Am J Ophthalmol. 1997; 124:765-774. 23. Shields CL, Shields JA, Armstrong T. Management of conjunctival and corneal melanoma with combined surgical excision, amniotic membrane allograft, and topical chemotherapy. Am J Ophthalmol. 2001;132:576-578. 24. Par...

Non healing wounds present a significant social and economic burden. Chronic non healing wounds are estimated to affect as many as 1-2% of individuals during their lifetime, and account for billions of dollars of expense annually on both a national and global basis. Our purpose is to describe the use of a novel dehydrated amniotic membrane allograft (EpiFix(®) ; MiMedx Group, Inc., Kennesaw, GA...

AIM In the light of interest being shown in amniotic membrane grafts for use in ocular surgery, this study aims to identify the bacterial contaminants commonly found on placental membranes from both caesarean and vaginal deliveries. METHODS Samples of placental membrane were taken following both elective caesarean and normal vaginal deliveries. Bacterial contaminants were identified. RESULT...

BACKGROUND Stevens-Johnson syndrome is often associated with blinding ocular surface cicatricial sequelae. Recent reports have described markedly improved clinical outcomes with the application of amniotic membrane to the ocular surface during the acute phase. Here we describe the clinical outcome of a patient with acute Stevens-Johnson syndrome and severe ocular surface involvement in whom the...

Human amniotic membrane proved to be a versatile and useful temporary biologic dressing in studies involving 120 patients. Wounds, both traumatic and nontraumatic in origin, responded to a protocol that allowed coverage of tissues as diverse as exposed bowel, pleura, pericardium, blood vessels, tendon, nerve and bone. Wounds unresponsive to usual therapeutic measures responded to membrane appli...