نتایج جستجو برای: amorph urate
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BACKGROUND Ultrasonography (US) and dual-energy computed tomography (DECT) can assess urate burden in gout. The objective of this study was to compare the quantification of urate deposition provided by US to the one provided by DECT. METHODS Patients with a diagnosis of gout were prospectively recruited to undergo quantification of urate deposition using US and DECT. US examination for tophi ...
In living organisms, the conversion of urate into allantoin requires three consecutive enzymes. The pathway was lost in hominid, predisposing humans to hyperuricemia and gout. Among other species, the genomic distribution of the two last enzymes of the pathway is wider than that of urate oxidase (Uox), suggesting the presence of unknown genes encoding Uox. Here we combine gene network analysis ...
INTRODUCTION Gout is increasing despite effective therapies to lower serum urate concentrations to 0.36 mmol/L or less, which, if sustained, significantly reduces acute attacks of gout. Adherence to urate-lowering therapy (ULT) is poor, with rates of less than 50% 1 year after initiation of ULT. Attempts to increase adherence in gout patients have been disappointing. We aim to evaluate the effe...
of disease process & therapeutic targets Hyperuricemia, as defined by a serum urate ≥6.8 mg/dl, is necessary but not sufficient to produce the clinical manifestations of gouty arthritis (gout) [1]. Hyperuricemia develops whenever there is a relative imbalance of production and excretion of urate. There are several other risk factors associated with the development of gout, mostly related to the...
WHAT IS KNOWN AND OBJECTIVE There are no clinical reports that have compared topiroxostat, a selective xanthine oxidase inhibitor, with allopurinol in serum urate-lowering efficacy. The aim of this study was to compare the efficacy and safety of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout. METHODS A phase 3, multicentre, randomized, double-blind, doubl...
BACKGROUND Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis. METHODS We first did a fixed-effects met...
Elevated serum levels of uric acid have been associated with an increased risk for gout, hypertension, cardiovascular disease, and renal failure. The molecular mechanisms for the diminished excretion of urate in these disorders, however, remain poorly understood. Human galectin 9, which is highly homologous to the rat urate transporter rUAT, has been reported to be a secreted or cytosolic prote...
Renal hypouricemia is an inherited and heterogeneous disorder characterized by increased urate clearance (CUA). The authors recently established that urate was reabsorbed via URAT1 on the tubular apical membrane and that mutations in SLC22A12 encoding URAT1 cause renal hypouricemia. This study was undertaken to elucidate and correlate clinical and genetic features of renal hypouricemia. The SLC...
The hyperuricaemia associated with gout is believed to be due to overproduction of uric acid, to impaired renal excretion of uric acid, or to alterations in both mechanisms (Seegmiller, 1966). In all likelihood, gout encompasses a heterogeneity of biochemical disorders, the metabolic or enzymatic bases of which with one exception, have not yet been completely delineated. The Lesch-Nyhan syndrom...
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