Amoxicillin (α-amino-p-hydroxybenzyl-penicillin) is a semi-synthetic, orally absorbed and widely prescribed β-lactam antibiotic. It is now widely used for eradication of gastric Helicobacter pylori infection combined with a second antibiotic and an acid‐suppressing agent despite its short elimination half-life of one hour. The purpose of this study was to develop and evaluate amoxicillin loaded...

introduction: the purpose of this in vitro study was to evaluate the antimicrobial effects of two antibiotics added to ah 26 sealer against enterococcus faecalis (ef). materials and methods: the antimicrobial effects of two antibiotic (amoxicillin and doxycycline) that were added separately to ah 26 sealer was evaluated by using the agar diffusion test and in vitro human root inoculation method...

background: the antibiotics are excreted after their effect on the host body and together with other waste disposal are entered the treatment plant processes. antibiotics prevent the biological sewage treatment in the plant which consequently causes hazards to the environmental and human health. the purpose of this study was to investigate the effect of some popular antibiotics used by human an...

Using a clinical pneumococcal strain for which MICs were 4, 2, and 32 mg/liter for penicillin, amoxicillin, and fosfomycin, respectively, we studied the efficacies of these antibiotics alone and their combinations in the treatment of prolonged (48-h) experimental fibrin clot infection in rabbits. Treatments were as follows: amoxicillin IV at 20 mg/kg of body weight in one dose (Amo20), 50 mg/kg...

Case 1. An increase in mortality occurred in a herd of 7000 free ranging Rhim gazelles (Gazella subgutturosa marica) in the UAE. Post-mortem revealed ruminal bloat and generalized haemorrhagic gastro-enteritis. Laboratory diagnosis confirmed Clostridium perfringens (direct smears and toxins found) enterotoxaemia and coli septicaemia. As this disease process was considered multifactorial, dietar...

We report a means of determining amoxicillin in bovine plasma by liquid chromatography with UV detection at 235 nm. Purification and concentration of extracts were accomplished by a tandem solid-phase extraction procedure with two reversed-phase columns. Separation of amoxicillin from interferences was improved by the incorporation of a crown ether in the solvent systems used both for the solid...

An analytical method based on solid phase extraction has been developed and validated for analysis of amoxicillin in human plasma using gemifloxacin as an internal standard. A COSMOSIL 5C18-PAQ column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves simple isocratic chromatographic conditions and mass spectrometric detection in th...

We evaluated some of the regimens recommended for the antimicrobial prophylaxis of infective endocarditis prior to dental extraction in 160 patients. Group A patients served as the control group, group B subjects rinsed their mouths with chlorhexidene, group C subjects took 3 g amoxicillin orally and group D patients took 600 mg clindamycin orally. The proportion of patients who had post-extrac...

A method for determining amoxicillin in human plasma by ESI-LC-MS/MS and using cephalexin as an internal standard was validated. The chromatographic separation was performed in a C18 Shim-pack CLC-ODS(M) analytical column (150 mm x 4.6 mm i.d. x 5 μm), which provided satisfactory separation of amoxicillin and cephalexin peaks, with analysis time of 3.1 minutes. A yield of extraction of 96.6% fo...