The aphorism was to develop new chemical entities as potential anticancer, anti-inflammatory, and analgesic agents. The Leuckart synthetic pathway was utilized in development of novel series of 2-(substituted phenoxy)-N-(1-phenylethyl)acetamide derivatives. The compounds containing 1-phenylethylamine as basic moiety attached to substituted phenols were assessed for their anticancer activity aga...

A series of 1-(2-hydroxyethyl)-3,5-dimethylpyrazolylazo derivatives, incorporating thiosemicarbazide 2a-c, 1,3,4-thiadiazole 3a-c, and 1,2,4-triazole-3-thione 4a-c were synthesized. The structure of these novel synthesized compounds 2a-c, 3a-c, and 4a-c was confirmed by spectral analysis. All these compounds were screened for their analgesic activity. Hot-plate and tail-immersion tests were use...

The ethanolic extract of Wedelia chinensis (EEWC) belonging to the family of Asteraceae was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its by using on carrageenan, mediators such as histamine and serotonin induced paw oedema, and cotton pellet induced granuloma tests for its effect on acute and chronic ...

Article history: Received on: 06/02/2017 Accepted on: 30/03/2017 Available online: 30/06/2017 Objectives: The present research work is designed to synthesize some new series of quinazoline-4-one/4-thione derivatives by modifying the structures retaining the fundamental structural features for the biological activity and screened for their anti-microbial, analgesic and anti-inflammatory properti...

nimodipine, an l-type calcium channel blocker, can induce analgesia. however, it is not clear that this analgesic effect is at the level of spinal or supraspinal pain pathway. in addition, it has been reported that the analgesic effect of nifedipine, another l-type calcium channel blocker is related to the hpa axis, but there is no report indicating the role of this axis in the analgesic effect...

Background and objectives: Pain is a primarily protective in nature, but often causes discomfort. Currently available analgesic drugs are not useful in all cases due to their side effects. Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects, such as, Teucrium polium (TP) used traditionally to relieve hea...

objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...

A narcotic or a non-narcotic analgesic that would not cause respiratory depression and addiction in may be used as an alternative to morphine. In Ayurveda a large number of indigenous drugs have been mentioned possessing the analgesic properties e.g Guggul, Erand, Rasna, Bhringaraja, Methika, palandu and prasikayavani. Total alcoholic extracts of Bhringaraja (Eclipta alba) was undertaken to stu...

OBJECTIVE The present study was carried out to investigate the possible in vivo analgesic, neuropharmacological and anti-diarrheal activities of the methanol extract of Jatropha gossypifolia fruits. MATERIALS AND METHODS The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuropharmacological activities were evaluated by hole cross, hole-board, and elevate...