The development of sound Analytical method(s) is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method development, optimize and validation of the method for the drug product from the developmental stage of the formulation to commercial batch of the product. Method d...

abstract: a time domain semi-analytical solution to study thermoelastic creep behavior of  functionally graded rotating axisymmetric disks with variable thickness is presented. the rate type governing differential equations for the considered structure are derived and analytically solved. to solve these  equations, the disk is divided into some virtual sub-domains. general solution of  equilibr...

in this paper, we present an analytical method for solving a well-posed boundary value problem of mathematical physics governing the vibration characteristics of an internal flow propelled fluid-structure interaction where the pipeline segment is idealized as an elastic hollow beam conveying an incompressible fluid on a viscoelastic foundation. the effect of coriolis and damping forces on the o...

Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability and consistency of analytical results; it is an integral part of any good analytical practice. It is the process of defining an analytical requirement, and confirms that the meth...

The reproducibility of a validated analytical method may require reassessment because of various reasons, such as the transfer between laboratories or companies, changes in the instruments or software platforms (or both), or changes in critical reagents, among others. This paper is a demonstration of an assay bridging study in evaluating reproducibility. The approach is simple but very informat...

A method is described for predicting whether a visual display terminal (VDT) will appear to flicker given the display phosphor persistence, refresh frequency, luminance and other environmental factors such as the distance between the user and the VDT. Based on research on human temporal sensitivity (Kelly 1969), one can predict the maximum screen luminance and the minimum refresh frequency that...

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