The epithelial-mesenchymal transition (EMT) is a complex cancer progression that can boost the metastatic potential of transformed cells by inducing migration, loss of cell adhesion, and promoting proliferation under anchorage-independent conditions. A DNA microarray analysis was performed comparing parental anchorage-dependent MDCK cells and anchorage-independent MDCK cells that were engineere...

INTRODUCTION Various anchorage techniques have been designed for canine retraction. Intraoral techniques have not always been successful, and now implants are widely used for this purpose. A new type of titanium microimplant, with a small diameter and a button-like head, was shown to be an effective source of anchorage for distal movement of the canines. The purposes of this study were to measu...

373 ABSTRACT E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstrate that anchorage-independent ILC cells show an increase in nuclear p120, which resu...

BACKGROUND Orthodontic protraction of mandibular molars without maxillary counterbalance extraction in cases of aplasia or extraction requires stable anchorage. Reinforcement may be achieved by using either temporary anchorage devices (TAD) or a fixed, functional appliance. The objective was to compare the clinical effectiveness of both methods by testing the null-hypothesis of no significant d...

Acute myelogenous leukemia (AML) is a malignancy of the myeloid cells of the bone marrow. Recently, a number of groups have demonstrated that it is possible to study the malignant phenotype at the level of DNA through gene transfer experiments. We have used such an approach to determine whether it is possible to transfer the malignant phenotype of anchorage independence from human AML cells to ...

Maxillary protraction headgear has been used in the treatment of Class III malocclusion with maxillary deficiency. However, loss of dental anchorage has been reported with tooth-borne anchorage such as lingual arches and expansion devices. This side effect can be minimized with skeletal anchorage devices such as implants, onplants, mini-implants, and miniplates. The use of miniplates for maxill...

Tetraploid and near-tetraploid chemically transformed derivatives of the pseudodiploid hamster line BHK 21/clone 13 were prepared in four different ways and their ability to be suppressed for anchorage independ ence by fusion to the anchorage-dependent parental line was tested. In all cases the presence of a single normal genome, thought on genetic grounds to contain a single suppressor gene, w...

clusions often requires intrusion and retraction of the anterior segment, which, in turn, usually necessitate mechanical reinforcement of posterior anchorage.1 Intraoral devices such as transpalatal bars or Nance appliances2 can reduce the need to wear Class II elastics, but can cause mesial movement of the lower first molars and protrusion of the incisors. Additional extraoral anchorage in the...