Introduction: The use of BMP-2 plays an important role in the treatment of extensive bone defect. However, data about the optimal dosage of BMP-2 in the massive bone defect cases is rare. Material and Method: Twenty-five SD rats were randomly divided into a control group ofhydroxyapatite (HA) alone (Group I), HA+BMP-2 1µg/mL (Group II), HA+BMP-2 5 ug/mL (Group III), HA+BMP-2 10 µg/mL (Gro...

  Objective: Alveolar ridge preservation in patients with inadequate bone volume is one treatment option for successful implant placement and can be done by using bone graft materials. On the other hand, Ceno Bone has been recently produced by Hamanand Saz Baft Kish Co. as a bone bioimplant of allograft origin. This study aimed to assess the clinical, histologic and histomorphometric results of...

both anorganic bovine bone (abb) and β-tricalcium phosphate (β-tcp) are used in clinical practice as bone substitute materials, but there is limited data comparing these two materials in standardized defects. the aim of this study was to histologically evaluate the effectiveness of abb and β-tcp in the healing of experimentally induced bone defects.eighteen bone defects were created on the calv...

currently autografts are gold standards for craniomaxillofacial bone regeneration. but autografts have some limitations. bone tissue engineering has been introduced to overcome these limitations. it consist three components: stem cells, growth factor, and scaffold. scaffold provides an environment for bone growth and simplifies cell adhesion, differentiation and proliferation. in this review, a...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Background & Objective: This study aimed to investigate the effect of decellularized allogeneic bone graft enriched by periosteal stem cells (PSCs) and growth factors on the bone repair process in a rabbit model, which could be used in many orthopedic procedures. Methods: In this experimental study, a critical size defect (CSD) (10 mm) was created in the ...