Androgens control male sexual development and maintenance of the adult male phenotype. They have very divergent effects on their target organs like the reproductive organs, muscle, bone, brain and skin. This is explained in part by the fact that different cell types respond differently to androgen stimulus, even when all these responses are mediated by the same intracellular androgen receptor. ...

The aim of the paper is to reveal phenotypic characteristics androgen-receptor-positive breast cancer in triple-negative cancer.
 Materials and Methods. authors analyzed clinical morphological tumour data 253 patients with morphologically verified invasive (TNBC). were treated at Regional Clinical Oncologic Dispensary (Ulyanovsk) Breast Pathology Department National Medical Research Center...

The course of rnammalian sexual differentiation is largely under the control of the principal male gonadal steroid, the androgen testosterone. Despite the importance of androgens in the rnediation of sexual differentiation, the molecular basis of androgenic activity in the central nervous system remains poorly characterized. Calcitonin gene-related peptide (CGRP) has previously been reported to...

Androgens are intricately involved in reproductive and aggressive behaviors, but the role of the androgen receptor in mediating these behaviors is less defined. Further, activity of the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal axis can influence each other at the level of the androgen receptor. Knowledge of the mechanisms for androgens' effects on behaviors through...

Recent research into cancer stem cells has refined our knowledge of the origins, maintenance, and progression cancer. The characteristics tumor initiating stem-like properties side populations that appear to be responsible for maintenance metastasis have given insights potential targets elimination treatment-resistant residual cells. These also provided inroads understanding preventing invasive...

Using the synthetic androgen R1881 (17 beta-hydroxy-17alpha-methyl-estra-4, 9, 11-trien-3-one) as probe, we identified cytoplasmic androgen receptors in baboon myocardium. The relative binding affinity of selected steroids for the androgen receptor was R1881, 100%; 5alpha-dihydrotestosterone, 32.6%; testosterone, 29.6%, progesterone, 7.2%; R5020, 1.0%; and estradiol-17beta, 5.8%. The androgen r...

OBJECTIVE To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67. MATERIALS AND METHODS Expressions of androgen receptor, CK-5/6 and Ki-67 were determined by immunohistochemistry in paraffin-embedded sections obtained from 86 invasive breast cancer cases of stages I/IIa/IIb in 4 molecular subtypes. Patient...

We have examined the nature of the mutant androgen receptor in a family with a severe defect in virilization associated with a qualitative defect in receptor function. The androgen receptor gene in this family contains two structural alterations: a single nucleotide substitution at position 2444 in exon 5 (adenosine----guanosine) that converts tyrosine 761 to a cysteine residue and a shortened ...

The cloning of a cDNA for the human androgen receptor gene has resulted in the availability of cDNA probes that span various parts of the gene, including the entire steroid-binding domain and part of the DNA-binding domain, as well as part of the 5' region of the gene. The radiolabeled probes were used to screen for androgen receptor mutations on Southern blots prepared by restriction endonucle...