BACKGROUND Fluridil, a novel topical antiandrogen, suppresses the human androgen receptor. While highly hydrophobic and hydrolytically degradable, it is systemically nonresorbable. In animals, fluridil demonstrated high local and general tolerance. OBJECTIVE To evaluate the safety and efficacy of a topical anti- androgen, fluridil, in male androgenetic alopecia. METHODS In 20 men, for 21 da...

Introduction. 5a-reductase inhibitors (5a-RIs), finasteride and dutasteride, have been approved for treatment of lower urinary tract symptoms, due to benign prostatic hyperplasia, with marked clinical efficacy. Finasteride is also approved for treatment of hair loss (androgenetic alopecia). Although the adverse side effects of these agents are thought to be minimal, the magnitude of adverse eff...

The appearance of hair plays an important role in people's overall physical appearance and self-perception. With today's increasing life-expectations, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this and is delivering active products directed towards meeting this consumer demand. The discovery of pharmacological targets and the developme...

BACKGROUND Scalp dermoscopy plays an important role in the diagnosis of hair and scalp disorders, and specific dermoscopic patterns have recently been associated with several disorders causing noncicatricial alopecia, such as androgenetic alopecia, alopecia areata, trichotillomania, and tinea capitis. OBSERVATIONS We describe the morphologic and pathologic features of a new dermoscopic patter...

results: the most important diseases to consider in the differential diagnosis of fphl include chronic telogen effluvium (cte), permanent alopecia after chemotherapy (pac), alopecia areata incognito (aai) and frontal fibrosing alopecia (ffa). this review describes criteria for distinguishing these conditions from fphl. conclusions: the only approved treatment for fphl, which is 2% topical minox...

Alopecia areata (AAR) and androgenetic alopecia (AGA) are two major forms of alopecia based on altered hair growth condition. In general, the cell cycle is regulated by several mechanisms including the stem cell factor/c-kit signaling. To assess a role for stem cell activity in alopecia, we performed histopathological, immunohistochemical, and semiquantitative analyses of c-kit as well as Ki-67...

The hair follicle is a complete mini-organ that lends itself as a model for investigation of a variety of complex biological phenomena, including stem cell biology, organ regeneration and cloning.  The arrector pili muscle inserts into the hair follicle at the level of the bulge- the epithelial stem cell niche.  The arrector pili muscle has been previously thought to be merely a bystander and n...

BACKGROUND Platelet-rich plasma (PRP) has been suggested as a therapeutic intervention for female androgenetic alopecia. OBJECTIVE To perform a pilot study on the effect of PRP scalp injections in women with female androgenetic alopecia. MATERIALS AND METHODS This double-blind, multicenter, placebo-controlled study compared the effect of PRP with that of saline placebo as scalp injection. T...