There are few cohort studies describing the adaptive functioning profile for Pitt-Hopkins syndrome (PTHS). In this study we examine PTHS and compare it to Angelman (AS). Caregivers of 14 individuals with PTHS, 33 deletion AS 23 non-deletion AS, completed Vineland Adaptive Behavior Scales-II. The in was characterised by strengths socialisation, followed motor skills, communication then daily liv...