Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently however, endothelial cells themselves have been found to produce angiogenesis inhibitors including delta-like 4 and vasohibin 1. These intrinsic ...

Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation further modifications cell behavior, which critical for tumor progression. Angiogenesis therapeutic resistance known to be modulated by hypoxia other microenvironments, such as acidic stress, both core features glioblastoma microenvironment. Hypoxia has also been shown pro...

Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti-angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recen...

Objective: The equilibrium of angiogenesis stimulus agents and angiogenesis inhibitory agents is an important factor in the increase of diabetic cardiomyopathy. This research aimed to survey the result of eight weeks of high-intensity interval training (HIIT) and moderate continuous (MICT) on the myocardium angiogenesis agent and histological alterations within male diabetic rats. Materials an...

Objectives We aimed to investigate the effects of juglone on angiogenesis, metastasis and cell proliferation processes in pancreatic cancer (PC) understand whether its possible occur via Wnt signaling pathway by analyzing expression levels target genes signaling. Background PC is a silent lethal type which can only be detectable after angiogenesis occured. The one pathways that plays an active ...

Heme-oxygenases (HOs) catalyze the conversion of heme into carbon monoxide and biliverdin. HO-1 is induced during hypoxia, ischemia/reperfusion, and inflammation, providing cytoprotection and inhibiting leukocyte migration to inflammatory sites. Although in vitro studies have suggested an additional role for HO-1 in angiogenesis, the relevance of this in vivo remains unknown. We investigated th...

tumor angiogenesis shown by microvessel count (mvc) or microvessel density (mvd), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. this article is payed to correlation between clincopathologic factors and tumor angiogenesis. in this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine c...

objective(s): progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. material and methods: adult female nmri mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

abstract our previous studies showed that various extracts of persian shallot (allium hirtifolium) have anti-angiogenic effects. this study has been undertaken to isolate and identify the major effective anti-angiogeneic sub-fraction of shallot. after preparation of the 50% hydroalcoholic extract of shallot bulbs, the extract was successively fractionated into n-hexane, ethyl acetate, n-butanol...