OBJECTIVE To determine whether there is a difference in disease severity between familial and sporadic primary open-angle glaucoma (POAG). METHODS A cross-sectional study design compared the distribution of Glaucoma Inheritance Study in Tasmania (GIST) severity scores of patients with genealogically confirmed familial POAG and those with sporadic POAG. The GIST severity scores provide a combi...

BACKGROUND 5-Fluorouracil, an antimetabolic agent, improves the success rate of trabeculectomies by inhibiting subconjunctival fibrosis. However, complications may be associated with early postoperative use. We investigated the outcome of needling revision with delayed subconjunctival 5-fluorouracil in failing filtering blebs after a trabeculectomy in patients with medically poorly controlled g...

Optical coherence tomography is a high resolution, rapid, and noninvasive diagnostic tool for angle closure glaucoma. In this paper, we present a new strategy for the classification of the angle closure glaucoma using morphological shape analysis of the iridocorneal angle. The angle structure configuration is quantified by the following six features: (1) mean of the continuous measurement of th...

PURPOSE This study investigates the inflammation in the anterior chamber in eyes with primary angle closure glaucoma (PACG) and evaluates the effect of intraocular pressure (IOP) elevation on the blood-aqueous barrier (BAB). METHODS Thirty-five patients (35 eyes) with acute primary angle closure glaucoma (APACG), 42 patients (42 eyes) with chronic primary angle closure glaucoma (CPACG), and 5...

A quantitative measure of visual field loss associated with kinetic perimetry in chronic open-angle glaucoma (COAG) is discussed. With this new technique an analysis of covariance is applied to a retrospective study of 41 COAG patients. It suggests that reduction of intraocular pressure may not be uniformly effective in controlling the progression of the disease.

Most glaucoma surgeries involve creating new aqueous outflow pathways with the use of a small surgical instrument. This article reported a microscope-integrated, real-time, high-speed, swept-source optical coherence tomography system (SS-OCT) with a 1310-nm light source for glaucoma surgery. A special mechanism was designed to produce an adjustable system suitable for use in surgery. A two-grap...

Canaloplasty is a highly effective, minimally invasive, surgical technique indicated for the treatment of open-angle glaucoma that works by restoring the function of the eye's natural outflow system. The procedure's excellent safety profile and long-term efficacy make it a viable option for the majority of glaucoma patient types. It can be used in conjunction with existing drug based glaucoma t...

PURPOSE To evaluate postoperative outcomes and success after combined phacoemulsification and glaucoma surgery with Ex-PRESS miniature implant compared with combined surgery with standard trabeculectomy. METHODS In this prospective series of 40 consecutive eyes we compared 20 eyes in 17 patients treated with combined phacoemulsification and glaucoma filtering surgery with the Ex-PRESS miniatu...

TBE purpose of this communication is to record a series of cases of acute closed-angle glaucoma which appear to have resolved permanently without operation because of shortening of a segment of the iris. This shortening of a segment of the iris has been great enough, we believe, in these cases to eliminate relative "pupillary block" and therefore iris bombe; enough residual angle has then opene...

Closed-angle glaucoma is the result of two mechanisms acting either separately or in combination: 1. Pupil block creates a greater pressure in the posterior than in the anterior chamber, pushing the iris on to the cornea. 2. Increased trabecular meshwork outflow in the presence of pupil block creates a lower pressure in the anterior chamber than in the posterior, pulling the iris on to the corn...