N eurofibromatosis 2 (NF2) is an autosomal dominant disease that is caused by inactivating mutations of the NF2 tumour suppressor gene. 2 Multiple central and peripheral nervous system tumours and ocular abnormalities are common in NF2; bilateral vestibular schwannomas are pathognomonic for the disease. Genotype-phenotype correlations are well established for NF2 associated tumours. In general,...

Xenografts--as simplified animal models of cancer-differ substantially in vasculature and stromal architecture when compared to clinical tumours. This makes mathematical model-based predictions of clinical outcome challenging. Our objective is to further understand differences in tumour progression and physiology between animal models and the clinic. To achieve that, we propose a mathematical m...

A 1-year-old, male, lop-eared rabbit presented for anorexia and weakness. dental trim medical treatment gastrointestinal stasis were implemented. Owners reclaimed the animal after 2 days. Two-weeks later, its condition had worsened, regurgitation was observed. Thoracic radiographs followed by barium contrast oesophagram revealed bronchopneumonia megaoesophagus. computed tomographic examination ...

BACKGROUND High-intensity focused ultrasound is a valuable tool for minimally invasive tumour ablation. However, due to the air content in ventilated lungs, lung tumours have never been treated with high-intensity focused ultrasound. Lung flooding enables efficient lung sonography and tumour imaging in ex vivo human and in vivo porcine lung cancer models. The current study evaluates the effecti...

Giant cell tumour (GCT) is a benign, locally aggressive tumour of the bone that accounts for 5% of primary bone tumours and 21% of benign bone tumours. This tumour more commonly presents as a single (solitary) lesion; however, it may appear with multiple (multicentric) lesions in less than 1% of the cases. According to the literature, 1-9% of solitary GCTs metastasizes to the lung, more commonl...

In an editorial entitled 'Fiber carcinogenesis: is asbestos the only hazard?', Stanton (1974) drew attention to the possibility that inhaled fibres other than asbestos, and in particular glass fibres, could be carcinogenic to humans. The hypothesis was based on experiments carried out on rats. Specially-bred experimental animals were subjected to intrapleural application of large numbers of spe...

Background: Salivary gland tumours are relatively uncommon and constitute 3% to 10% of all head & neck neoplasms. The majority salivary arise in the parotid gland.
 Objectives: To search clinicopathological presentation tumours.
 Methods: This was a cross sectional study.
 Results: highest incidence benign tumors 3rd 4th decade, whereas for malignant tumor it 5thdecade life. ...

Measurements of extracellular pH (pHe) in vivo have shown that the microenvironment in tumours is more acidic than in normal tissue. However, both human and animal tumour cells have been shown to have an intracellular pH (pHi) on the alkaline side of neutrality (pH 7.1-7.2). This gives rise to a reversed pH gradient between tumours and normal tissue which implies that cells within solid tumours...

INTRODUCTION SPC-raf and SPC-myc transgenic mice develop disseminated and circumscribed lung adenocarcinoma respectively, allowing for assessment of carcinogenesis and treatment strategies. The purpose of this study was to investigate the technical feasibility, the correlation of initial findings to histology and the administered radiation dose of combined micro-PET/micro-CT in these animal mod...