Background: Infertility problem affects 20-30% of young couples. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer which its side effect may last up to the end of the life. The aim of the present study is to investigate the effect of GnRH on viability of ovarian follicles defect produced by anticancer drug. Materials and Methods: In the present study ad...

These experiments employ the photoisomerizable compound, 3,3'bis-[a-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium . In homogenates from the heart, transBis-Q blocks the binding of [3H]-N-methylscopolamine to muscarinic receptors . In voltage-clamped atrial trabeculae, trans-Bis-Q blocks the agonist-induced potassium conductance. The ...

The existence of neural opioid-mediated networks that are specific for the modulation of nociception is well established. Parallel non-opioid pathways exist, but their underlying physiology is little known. We now report that oxytocin administered intraperitoneally to rats, and intraperitoneally or intracisternally to mice has an anti-nociceptive effect, which is related to the activation of de...

We have previously reported the anti-neoplastic properties of ~-methylthio-4-amino-5-hydroxymethylpyrimidine (methioprim) and of other related pyrimidines with modification of the 2alkylthio substituent (2). These compounds were initially chosen for study following the observations of Guthrie et a/. that collateral sensitivity for methioprim was demonstrable in amethopterin-resistant strains of...

On 25 June 2008 the US Food and Drug Administration held a public Advisory Committee Meeting of its Cardiovascular and Renal Drugs Division on Tolvaptan (NDA 22-275), the first oral vasopressin antagonist to apply for licensing (http://www.fda.gov/ohrms/dockets/ac/cder08.html# CardiovascularRenal). Based on the comments made, we may now expect that tolvaptan will make it to the pharmacies soon....

Antiemetics play a key role in hematopoietic cell transplantation (HCT). High-dose chemotherapy and total body irradiation (TBI) have high emetogenic potential, vomiting nausea during conditioning regimen thereafter impair oral intake, which can lead to weight loss, hyperglycemia due parenteral nutrition, infectious disease, increased transplant-related mortality. We searched for randomized tri...