GnRH antagonists have been used with increasing frequency in assisted reproduction treatments over the past few years and have been associated with quicker and more profound LH suppression and shorter treatment cycles than conventional GnRH agonists. Usually, these are commenced on day 6 of FSH stimulation without allowing for patient variation in response to treatment. The study was aimed at i...

OBJECTIVE To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to in vitro fertilization (IVF). STUDY DESIGN A retrospective study in Akdeniz University, Faculty of Medicine, Department of Obstetrics and ...

This article is a systematic review of the literature on utilization of gonadotrophin-releasing hormone antagonists (GnRH-ant) for ovarian stimulation for IVF in special patient groups. Summarized by meta-analysis are the data from randomized controlled trials (RCT) in which GnRH-agonist (GnRH-a) and GnRH-ant were compared (eight RCT for poor response, four RCT for PCOS). Also reviewed are the ...

To assess whether high BMI of >30kg/m2 affects outcome Intrauterine Insemination method(IUI). We conducted a retrospective study 140 infertile couples. Out these 71 women had <30 (Group A) and 69 >30 B). All undergone (IUI) using the agonist/antagonist with stimulation by gonadotrophins protocol. Statistical anylasis was done Student t test for parametric data Chi-square...

The interaction between the cardioprotective effect of endothelin (ET) receptor blockade and nitric oxide (NO) during ischemia-reperfusion injury was investigated. Anesthetized pigs were subjected to 45 (protocol 1) or 30 min (protocol 2) coronary artery ligation and 4 h reperfusion. In protocol 1, five groups were given vehicle, the ET(A) receptor antagonist LU-135252 (LU), the NO synthase (NO...

background: the purpose of present study was to evaluate the role of pre-ovulatory gnrh agonist therapy on ivf outcomes in gnrh antagonist cycles. methods: in this prospective study we recruited 100 infertile women undergoing ivf cycles with gnrh antagonists. the patients were assigned to two groups: group a (the study group, n=42) were assigned for receiving hcg+triptorelin for the final oocyt...

introduction: estimating ephedrine’s effect on animal’s locomotor activity and evaluation of cumin fruit essential oil (feo) effect and mechanism of ephedrine-induced hyper-locomotion. methods: a new protocol developed for evaluation of manic behavior induced by ephedrine in a dose and time dependent manner. following the suppressive effects of cumin feo on acquisition and expression of ephedri...