This study presents biodegradation of benzoic acid (BA) and anthranilic acid (AA) by Micrococcus sp. under aerobic conditions. Initial concentrations of BA and AA were varied (500-2500 mg/l) and almost complete biodegradation of BA and AA was observed within 30 h. Andrews kinetic model for single substrate was fitted to obtain maximum specific growth rates, half saturation and substrate inhibit...

Mixed ligand complexes of some transition metals[ Cu(II),Ni(II), Co(II) and Zn(II)] have been investigated Potentiometrically with Pyridine-2,6-dicarboxylic acid(PDA) and 2-hydroxy benzalidine-anthranilic acid (HBAA) in aqueous solution at 298.15 K and 313.15 K. The ionic strength of 0.1 mol dm-3 was kept constant using KNO3. The stability constants of these 1:1:1 ternary complex have been eval...

The conversion in vitro of kynurenine into kynurenic acid and anthranilic acid in both normal kidneys and those obtained from mice infested with Schistosoma mansoni was investigated. Normal mouse kidneys seem to possess an excess of functional pyridoxal phosphate over those obtained from infested mice. Kynureninase and kynurenine transaminase in the latter kidneys are more easily inhibited by d...

Using an immunohistochemical technique, we have studied the distribution of 3-OH-anthranilic acid (3-HAA) in the rat brain. Our study was carried out in control animals and in rats in which a stroke model (single transient middle cerebral artery occlusion) was performed. A monoclonal antibody directed against 3-HAA was also developed. 3-HAA was exclusively observed in the infarcted regions (ips...

The use of herbs or their parts: leaves, roots, rhizomes, flowers, seeds, natural strains, as well as extracts or isolated metabolites is becoming more and more popular. Natural remedies not only act prophylactically, but also help to alleviate symptoms of many diseases and enhance the overall functioning of the internal organs. Many raw materials of natural origin plays a role in treatment of ...

Novel anthranilic acid derivatives having substituted N-acyl side chains were designed and synthesized for evaluation as plasminogen activator inhibitor-1 (PAI-1) inhibitors. Compounds with a 4-diphenylmethyl-1-piperazinyl moiety on the acyl side chains in general exhibited potent in vitro PAI-1 inhibitory activity and good pharmacokinetic profiles after oral administration in rats. Compound 16...

Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using "Phase solubility study" with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K a...

The metabolism of n-tryptophan in man was recently studied by Langner and Berg (l), who found that about one-third to one-half of a 2 gm. dose was excreted unchanged in the urine. Considerable n-kynurenine and traces of indolepyruvic acid and acetyltryptophan were also excreted by their subjecm. Langner and Volkmann (2) found that acetyl-n-tryptophan was poorly absorbed and most of the compound...