chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. in the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and wistar rats by using the writhing and formalin-induced paw edema tests respectively. the activities of the compounds were compared with celecoxib as a referenc...

Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay. Results: The results showed that these flavonoids were n...

This study was conducted to investigate the in vitro anti-inflammatory, anti-elastase, procollagen production, and astringent activities of <i>Euphorbia thymifolia</i> extracts prepared using two solvents for cosmetic application focusing on skin aging. Extraction performed by solvent extraction method with methanol (EM) hot-water (EW). Astringent activity EM increased concentration...

Continuous input of pharmaceuticals into rivers, through wastewater treatment systems, may cause adverse effects on the aquatic ecosystems of the receiving waterbodies, due to the intrinsic biological activity of these compounds. To investigate this issue, we have carried out an Environmental Risk Assessment in the lower part of the Llobregat River basin (NE Spain). The survey was carried out a...

Natural antioxidants are abundant in food and medicinal plants. These natural antioxidants, particularly polyphenols carotenoids, have numerous biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis, anticancer properties. To examine potential cancer prevention agent sources advance their utilization useful varieties, drugs, added substances, it is fundamental for sep...

Dapsone 5% gel for the topical treatment for acne vulgaris was recently introduced in Canada. It represents the first new anti-acne agent to gain North American regulatory approval in the past decade. Dapsone's utility is attributable to its anti-inflammatory and antimicrobial properties that improve both inflammatory and non-inflammatory acne, with more prominent effects occurring in inflammat...

This review focused on the usage of bromelain in numerous applications, as well most recent literature chemistry, extraction, and purification from pineapple (Ananas comosus). Bromelain is a crude, aqueous extract obtained stems fruits pineapple, leading edible member family Bromeliaceae. contains mixture different thiol endopeptidases phosphatases, glucosidases, peroxidases, cellulases, & ...