For the first time, current review fully provides information on phytochemicals, applications, and pharmacological aspects relating to 3 Dalbergia species, Siamese Rosewood ( cochinchinensis Pierre ex Laness.), Indian D sissoo Roxb.), Brazilian nigra (Vell.) Benth.). Based chromatographic separation, phytochemical studies these plants have, date, resulted in isolation structural elucidation of ...

In the ancient time Eucalyptus globulus used for various purpose. It is a tall and an evergreen tree that can grow up to height of 70m its diameter about 4 to7ft. which was first found on island Tasmania in 1792 associate Myrtaceae family commonly called as Tasmanian Blue Gum, southern blue gum or are different names eucalyptus parts India. The particular species have been purposes. had rich so...

INTRODUCTION Aspirin has been used as an analgesic from time immemorial. But the recent advances on various aspects of it in reducing risk of various fatal and non fatal diseases warrant a re-look. OBJECTIVE This study has been undertaker to assess the anti inflammatory and analgesic action of aspirin and Nifedipine alone as well as in combination and their individual and synergistic effect a...

Background The medicinal uses of plants are in many cases based exclusively on traditional knowledge without enough scientific evidences. Different parts of Moringa oleifera were traditionally used for the treatment of wide variety of ailments including arthritis and joints pain. The present study had been designed to evaluate the anti-arthritic and anti-nociceptive activities of ethanol extrac...

OBJECTIVES Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test. MATERIALS AND METHODS Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days an...

Evidence in the past decade indicates that the mechanisms of anti-nociception of electroacupuncture (EAc) involve actions of neuropeptides (i.e., enkephalin and endorphin) and monoamines (i.e., serotonin and norepinephrine) in the central nervous system. Our present results using a subcutaneous injection of formalin to test pain sensation in mice provide further understanding of the involvement...

The purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. Seventy male Wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (S) (control group, 1.0 mL kg(-1)), morphine (MO) (4.0 mg kg(-1)), tramadol (TR) (12.5 mg kg(-1)), meloxicam (ML) (1.0 mg kg(-1)), tramadol-...

Introduction: Angiogenesis in the central nervous system is visible animal models of neuroinflammation and bone cancer pain. However, whether spinal angiogenesis exists contributes to sensitization neuropathic pain remains unclear. This study analyzes impact on Methods: Rats with chronic constriction injury (CCI) sciatic nerve underwent implantation an intrathecal catheter. Fumagillin or vascul...

BACKGROUND The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components. OBJECTIVES This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model. MATERIALS AND METHODS A total of 42 adult male rats were divided into seven groups: a c...

The present study investigated the hypothesis that urinary levels of N telopeptide (NTx) can be used to predict the anti‑nociceptive responses of zoledronic acid and paclitaxel on bone metastases in a rat model. Rats were implanted with intra‑femur Walker 256 carcinoma cells or control solution, and were treated with either normal saline, zoledronic acid or paclitaxel on the 10th day following ...