PURPOSE Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both drugs are available in tablet dosage forms with a dose of 150 mg for LAM and 300 mg ZID respectively. METHOD The method employed is based on first order derivative spectroscopy. Wavelengths 279 nm and 300 nm were selected for the estimation of the Lamovudine and Zidovudine respectively by t...

Errors in prescribing antiretroviral agents for patients with HIV infection may lead to treatment failure, drug resistance, or drug toxicity. Several published reports describe such errors, which appear to be related to a lack of knowledge, inexperience, complexities of the antiretroviral regimens, and sound-alike and look-alike names. Clinicians caring for patients with HIV infection should be...

DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we demonstrate that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry. This is associated with induction of dsRNAs derived at least in part from endogenous ret...

BACKGROUND Anti-retroviral treated HIV-infected patients are at risk of mitochondrial toxicity, but non-invasive markers are lacking. Serum FGF-21 (fibroblast growth factor 21) levels correlate strongly with muscle biopsy findings in inherited mitochondrial disorders. We therefore aimed to determine whether serum FGF-21 levels correlate with muscle mitochondrial dysfunction in HIV-infected pati...

Modern anti-retroviral therapy is highly effective at suppressing viral replication and restoring immune function in HIV-infected persons. However, such individuals show reduced physiological performance and increased frailty compared with age-matched uninfected persons. Contemporary anti-retroviral therapy is thought to be largely free from neuromuscular complications, whereas several anti-ret...

Viral load testing is the gold standard for HIV treatment monitoring, periodic viral tests are most accurate way of determining whether antiretroviral working to suppress replication HIV. The achievement suppression among persons living with has a lot benefits individual, community, and entire population level. Therefore, review aimed at summarizing documenting public health impact monitoring P...

Background: Acquired immune deficiency syndrome (AIDS) is now considered as a manageable chronic illness with the availability of ART. A high level adherence (>95%) required for antiretroviral therapy to be effective. It that builds vacuum in person affecting his/her quality life (QOL) whole. Aim& Objective: The aim our study was determine and its effect on their among HIV/AIDS patients ...

background: innovative bioactive films incorporated with antimicrobial agents have been recently developed for food preservation. the aim of this study was to evaluate antibacterial activity of polylactic acid (pla) films incorporated with ziziphora clinopodioides essential oil (zeo) and ethanolic propolis extract (epe) against some common food-borne pathogens. methods: the volatile chemical co...

background and objective:   the aim of the study was to evaluate the clinical effects of a mouthwash containing sage (salvia officinalis) extracts on streptococcus mutans (sm) causing dental plaque in school-aged children. material and methods: a double blind clinical trial study was conducted in a dormitory on 70 girls aged 11-14 years having the same socioeconomic and oral hygiene conditions....