Tissue transglutaminase 2 belongs to a family of transglutaminase proteins that confers mechanical resistance from proteolysis and stabilizes proteins. Transglutaminase 2 promotes transamidation between glutamine and lysine residues with the formation of covalent linkages between proteins. Transglutaminase 2 also interacts and forms complexes with proteins important in extracellular matrix orga...

BACKGROUND Fever is a physiological response activated by integrative interactions between the neuronal and immune systems. The association of fever with development autoantibodies against various self-antigens controversial. We here evaluated if was associated increased levels anti-tissue transglutaminase (tTG) IgA autoreactive antibodies in children. METHODS This case-control study performed ...

background: northeast iran has one of the highest rates of esophageal cancer in the world which is mainly squamous cell carcinoma (e scc). celiac disease (cd) has been identified as a risk factor for escc. the aim of this study is to determine the prevalence of cd in gonbad at northeast iran and probable relation between celiac and escc. materials and methods: fourteen hundred inhabitants of no...

The aim of this study is to assess the prevalence of isolated short stature as a clinical presentation of celiac disease in Saudi Arab children and whether some of the routine laboratory tests performed to determine the cause of short stature could suggest the diagnosis of celiac disease. A total of 91 children with short stature were included in the study. Extensive endocrine and biochemical a...

BACKGROUND Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. OBJECTIVE To investigate correlation between tTg levels and histological alterations and ...

Liver plasma membranes contain a morphologically distinct protein complex which serves as a substrate for the plasma membrane-associated transglutaminase. The complex, which appears as a two-dimensional sheet, is insoluble in sodium dodecyl sulfate and reducing agents and has been named SITS for sodium dodecyl sulfate-insoluble transglutaminase substrate (Tyrrell, D. J., Sale, W. S., and Slife,...