The present research work involves the synthesis of a total four Curcumin-NSAIDs conjugates and their subsequent biological screening for Rheumatoid Arthritis, Anti-inflammatory, Anti-ulcer activities. Curcumin is phytochemical having versatile therapeutic potential. idea conjugating curcumin with various NSAIDs somewhat novel in sense that it helps obtaining target incorporating certain desire...

Currently, photocatalytic reactions under solar illumination have attracted worldwide attention due to the tremendous set of associated environmental problems. Taking sunlight into account, it is indispensable develop highly effective photocatalysts. Strontium titanate, SrTiO3 (STO), a cubic perovskite-type semiconductor, an inexpensive material with high thermal stability and corrosion resista...

OBJECTIVE To evaluate the safety and efficacy of L-asparaginase as an immunosuppressive agent in a mouse model of rheumatoid arthritis. METHODS Male DBA/1 mice with collagen-induced arthritis (CIA) were treated at different intervals with various doses of native and pegylated L-asparaginase from E. coli. The mice were observed for 4 weeks during which time arthritis was scored. Outcome parame...

Vasoactive intestinal peptide (VIP) is one of the prospective candidates for clinical application in rheumatoid arthritis (RA). Its antiarthritic effect is associated with the suppression of inflammatory and autoimmune responses. The ability of VIP to trigger a shift towards Th2 immunity suggests that anti-infectious host resistance might be affected. In the present study VIP was applied at the...

AIM The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P. alba. MATERIALS AND METHODS Plumeria alba L. leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P. alba. This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively. T...

The main objective of the present work is to evaluate potential Lantana camara (aculeata) for anti-arthritic activity using in vitro and vivo study. L. an important medicinal, ornamental, essential oil-producing herb from family Verbenaceae. Different parts have been used treatment various human ailments such as itches, cuts, ulcers, swellings, bilious fever, eczema, tetanus, malaria, tumor, rh...

Glucosamine represents one of the most commonly used drugs to treat osteoarthritis. However, mechanisms of its antiarthritic activities are still poorly understood. The present study identifies a novel mechanism of glucosamine-mediated anti-inflammatory activity. It is shown that both glucosamine and N-acetylglucosamine inhibit IL-1beta- and TNF-alpha-induced NO production in normal human artic...

High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB1 promotes inflammation. Experimental studies demonstrate HMGB1 to be a pathogenic factor in many inflammatory conditions including arthritis. HMGB1-blocking therapies in arthritis models alleviate disease and confer signi...