We further examined the usefulness of previously reported Bacillus subtilis biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibit...

of most of the Candida strains tested was noticed, whereas the rest of the surface was covered with a thin layer of bacterial growth. Table 1 shows the mean number and the percentage of strains of C. albicans, as well as Candida of other species which inhibit the growth of the tested bacteria. The standard deviations of these mean numbers, for the 84 strains of C. albicans, were quite low, but ...

Two commercial databases (Pharmaprojects and Adis Insight R&D) were queried for antibacterial agents in clinical development. Particular attention was given to antibacterial agents for systemic administration. For each agent, reviewers were requested to indicate whether its spectrum of activity covered a set of selected multidrug-resistant bacteria, and whether it had a new mechanism of action ...

Polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA; C20:5n-3), are attracting interest as possible new topical antibacterial agents, particularly due to their potency and perceived safety. However, relatively little is known of the underlying mechanism of antibacterial action of EPA or whether bacteria can develop resistance quickly against this or similar compounds. Therefore, the...

Treatments for bovine mastitis based on antibiotic therapy are not always effective which may lead to faults in recovery of diseased animals, selection of resistant bacteria and the presence of antimicrobial residues in milk. In this context the use of essential oils configures as an alternative to control mastitis pathogens in dairy cows because they have antibacterial action against gram-posi...

This study investigates the antibacterial mechanism of action of electrospun chitosan-based nanofibers (CNFs), against Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus and Listeria innocua, bacteria frequently involved in food contamination and spoilage. CNFs were prepared by electrospinning of chitosan and poly(ethylene oxide) (PEO) blends. The in vitro antibact...

In recent years, there has been considerable interest in the potential antibacterial properties that bioactive glasses may possess. However, there have been several conflicting reports on the antibacterial efficacy of 45S5 Bioglass(®). Various mechanisms regarding its mode of action have been proposed, such as changes in the environmental pH, increased osmotic pressure, and 'needle-like' sharp ...

Yotis, William (Loyola University, Hines, Ill.), and Ronald Stanke. Bacteriostatic action of progesterone on staphylococci and other microorganisms. J. Bacteriol. 92:1285-1289. 1966.-Progesterone has been examined in vitro for antibacterial activity against 10 microorganisms. Turbidimetric and manometric techniques were used to assay the antibacterial activity of progesterone. The organisms tes...

Cinnamon has been used for neuralgia on the knees and waist, and it is shown to have a wide antibacterial spectrum in both Gram-positive bacteria and Gram-negative bacteria. In this study, glucosyltransferase adhesive ability, acid-production suppression effect, and antibacterial activity were measured to identify the anti-caries effect of cinnamon extract. It was shown that cinnamon extract ef...

In response to the wide spread of microbial contamination induced by bacterial pathogens, the development of novel materials with excellent antibacterial activity is of great interest. In this study, novel antibacterial chitosan (CS) and polyhexamethylene guanidine hydrochloride (PHGC) dual-polymer-functionalized graphene oxide (GO) (GO-CS-PHGC) composites were designed and easily fabricated. T...