The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. So, intensive efforts are underway worldwide to develop new antimicrobial agents. To identify compounds with a potent antimicrobial profile, we designed and synthesized low molecular weight 2-mercaptobenzothiazole derivatives 2a-2l and 3a-3l. Both series were scree...

There is a pressing need to develop novel antibacterial agents given the widespread antibiotic resistance among pathogenic bacteria and the low specificity of the drugs available. Endolysins are antibacterial proteins that are produced by bacteriophage-infected cells to digest the bacterial cell wall for phage progeny release at the end of the lytic cycle. These highly efficient enzymes show a ...

Background: Clean wounds are a frequent occurrence in the medical field and medical providers provide varied advice for wound care. Topical antibacterial ointments are commonly used to facilitate wound healing in patients with these types of wounds. Topical antibacterial ointments have been shown to cause allergic contact dermatitis, may cause an increase in antibiotic resistance, and may be eq...

........................................................................................................................................... 1 SAMMANFATTNING ........................................................................................................................... 2 INTRODUCTION ........................................................................................................

BACKGROUND The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents. OBJECTIVES This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp., an endophytic fungus associated with leaves of Garcinia nobilis. METHODS The cult...

There is a significant need to develop antibacterial materials that could be applied locally and directly to the places surrounded by large amount of bacteria, in order to address the problems of bacterial antibiotic-resistance or irreversible biofilm formation. Hydrogels are thought to be suitable candidates due to their versatile applications in biomedical field. Among them, small molecular h...

The present study examined the mechanism for caries resistance and the pulp responses in vital teeth following the use of the augmented-pressure adhesive displacement technique. Dentin adhesives were applied to the surface of sound dentin disks in 4 experimental groups: non-antibacterial adhesive and gentle adhesive displacement (N-G), non-antibacterial adhesive and augmented-pressure adhesive ...

Over 10,000 research scientists attended the ICAAC meeting in Toronto, Canada. The continued increase in the rate of resistance in bacteria and fungi and the underlying mechanisms of resistance were the focus of many presentations this year. So, too, were the attempts to combat this emerging resistance crisis. Many papers described new modifications to older antimicrobials, novel classes of ant...