angioedema secondary to c1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. a genetic defect of c1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported. in lupus patients, angioedema may be the result of an a...

Abstract Maternal and cord blood sera were collected from 20 parturients who received the BNT162b2 vaccine. All women infants positive for anti S- anti-receptor binding domain antibody–specific immunoglobulin G. Cord antibody concentrations correlated to maternal levels time since vaccination. Antenatal severe acute respiratory syndrome coronavirus 2 vaccination may provide neonatal protection.

Fragile X syndrome (FXS) develops from excessive trinucleotide CGG repeats in the 5'-untranslated region at Xq27.3 of the Fmr-1 gene, which functionally silences its expression and prevents transcription of its protein. This disorder is the most prominent form of heritable intellectual deficiency, affecting roughly 1 in 5,000 males and 1 in 10,000 females globally. Antibody specificity and sele...

Rosen, F. S. : Hereditary splenic hypoplasia. PEDIATRICS, 42:752, 1968. 8. Alper, C. A., Abramson, N., Johnston, R. B., Jr., McCall, C. E., Jandl, J. H., and Rosen, F. S.: Increased susceptibility to infection associated with a defect of complement metabolism. J. Clin. Invest., 47: la, 1968. 9. Kretschmer, R., Janeway, C. A., and Rosen, F. S.: Immunologic amnesia. Pediat. Res., 2:7, 1968. 10. C...

Eighteen human immunodeficiency virus (HIV)-seropositive patients were found among 211 previously treated adult patients with a variety of leukemias who had been multiply transfused before April 1985. Patients known to be homosexual or intravenous drug users were excluded from this study. The spouse of one HIV-seropositive patient became HIV infected and subsequently developed the acquired immu...

Trends in human immunodeficiency virus (HIV) counselling and antibody testing at a London clinic for sexually transmitted diseases showed substantial changes over a 12 month period. From around 100 a month in the summer of 1986 the numbers of people attending rose substantially to 276 in October 1986 and 475 in November at the time of the campaign in the popular press. They rose further still, ...

Recent Department of Health and Social Security (DHSS) guidelines on screening procedures for antibody to human T cell lymphotropic virus type III (HTLV-III) have stressed the importance of providing adequate counselling for patients before and after testing. The establishment of a national acquired immune deficiency syndrome (AIDS) counselling training unit has enabled large numbers of Nationa...

Androgen deficiency in women has been recognized as a distinct clinical syndrome that affects thousands of women particularly women in the postmenopausal period of their life. This syndrome has been described by several names including female androgen deficiency syndrome as well as hypoactive, sexual desire disorder. A recent large survey concerning sexual problems in women also adds personal d...

Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syn...

A 15-year-old boy with a 13-year history of periodic fevers, lymphadenopathy, and leukocytosis showed virological, serological, immunohistologic, and molecular evidence of persistent, active, Epstein-Barr virus (EBV) infection. Acyclovir and several other agents failed to alter his clinical course. Comprehensive immunological studies could not identify a defined immune deficiency syndrome to ex...