Background and Purpose The aims of this prospective and multicenter study were to determine the frequency of anticardiolipin and antinuclear antibodies in an unselected ischemic and hemorrhagic stroke population and to evaluate the clinical significance of these autoantibodies. Methods Over a 1-year period, we collected plasma from 481 consecutive patients with ischemic or hemorrhagic stroke at...

BACKGROUND Diffuse alveolar haemorrhage (DAH) has been rarely reported in association with pulmonary infections. CASE PRESENTATION We report the case of a 43 year old immunocompetent man presenting with dyspnoea, fever and haemoptysis. Chest imaging showed bilateral ground glass opacities. Microbiological and molecular tests were positive for Mycobacterium tuberculosis and treatment with ison...

A 52-year-old man was admitted to hospital with chest pain after physical activity. Emergency coronary angiography showed multiple thromboembolic occlusions in the anterior descending coronary artery and in the right coronary artery. Further testing revealed anticardiolipin and 2-glicoprotein antibodies (the patient had been diagnosed for ulcerative colitis and polymyalgia rheumatica). Heparin...

Background: Anticardiolipin (ACL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this study was to investigate the prevalence and prognostic implication of ACL antibodies in patients with Non-Hodgkin’s lymphoma (NHL). Methods: Sixty-four patients with NHL were included in this study. Enzyme-linked immunosorbent assay kits were used to measure the c...

Most patients with lupus anticoagulant (LA) activity have coincident antibodies to a group of negatively charged phospholipids, and its is suggested that LA and anticardiolipin tests detect antibodies with overlapping specificities. Some discordance between the two assays has been described, however. One patient presenting with severe thrombotic disease (recurrent deep vein thrombosis, pulmonar...

R a Abstract. Production of factor VIII or factor IX inhibitors is a major complication limiting the efficiency of substitutive therapy in haemophiliacs. Moreover, viral infections, the second serious complication of replacement therapy, may be associated to the occurrence of antiphospholipid antibodies which paradoxically lead to thrombosis. We investigated the prevalence of coagulation inhibi...

The case of a 20 year old woman is reported with Budd-Chiari syndrome in whom lupus anticoagulant and anticardiolipin antibodies were shown; treatment with oral anticoagulants induced a considerable improvement. This treatment was interrupted after one year; interruption was followed by redevelopment of ascites. Further treatment with anticoagulants was continued for five years with noticeable ...

In a previous paper, Tringali, Del Carpio, and Gismmanco (1966) reported that treatment of sera with 2-Mercaptoethanol (2-ME) caused a disappearance of non-syphilitic anticardiolipin reactivity, usually referred to as T'false positive" (EP) reactivity, as detected in a complement-fixation assay, However, similar treatment did not abolish the reactivity of syphilitic sera in the samie assay. Thi...