Breast cancer rarely metastasizes to the muscles, and it is even more unusual for this phenomenon to result in airway compromise. We present a unique case of an 84-year-old female who presented with neck swelling and upper airway obstruction due to metastatic breast cancer invading the sternocleidomastoid muscles. After establishing the diagnosis and discussing possible treatment options, the p...

Purpose: To present long-term results adjuvant neutron therapy in combined modality treatment of patients with primary-metastatic breast cancer. Material and methods: The studied included 53 stage T2-4N1-3M1 cancer, who underwent multimodality treatment: neoadjuvant chemotherapy (NACT) (ACT) according to CMF, CAF/FAC schemes, antiestrogen (if indicated), radical mastectomy (RM) radiotherapy usi...

Adenosarcoma of the uterus is a mixed epithelial-mesenchymal tumor containing benign glandular epithelial component with sarcomatous mesenchymal stroma. This rare tumor accounts for only 8% of all uterine sarcomas (1). It has been suggested that some cases of the uterine adenosarcoma may be associated with hyperestrinism due to the administration of tamoxifen and prior radiation exposure (1-3)....

Antiestrogen therapy is commonly used to treat estrogen receptor (ER)+ breast cancers but acquired and de novo resistance limits their overall curative potential. An endoplasmic reticulum stress pathway, the unfolded protein response, and autophagy are both implicated in the development of antiestrogen therapy resistance in estrogen receptor-α (ER) positive breast cancer. Thus, we recently inve...

Little is known about the cognitive factors associated with adherence to antiestrogen therapy. Our objective was to investigate the association between domain-specific cognitive function and adherence among women in a clinical prevention trial of oral antiestrogen therapies. We performed a secondary analysis of Co-STAR, an ancillary study of the STAR breast cancer prevention trial in which post...