In this study, the resistance to antifungal drugs was investigated among 51 strains of Candida tropicalis isolated from clinical samples in the State of Ceará, Brazil. Antifungal resistance was a rare finding in our study and was restricted to three (5.9%) of the strains of Candida tropicalis. These exhibited resistance to both fluconazole and itraconazole.

highly stabilized monodispersed silver nanoparticles (agnps) were synthesized by rhizopus stolonifer and the antifungal efficacy of silver nanoparticles (agnps) against candida sp. were studied. characterization of biosynthesized nanosilver was made by tem-eds and afm. minimum inhibitory concentration (mic) of biosynthesized agnps, amphotericin b, and fluconazole have been studied on pathogenic...

conclusions the monitoring of antifungal susceptibilities of candida species isolated from clinical sources is highly recommended for the efficient management of patients. moreover, the trailing effect should be taken into consideration once the interpretation of the results is intended. results among the tested antifungal drugs in this study, the highest rate of resistance was observed against...

Growing rates of fungal infections and increasing resistance against standard antifungal drugs can cause serious health problems. There is, therefore, increasing interest in the potential use of medicinal plants as novel antifungal agents. This study investigates the antifungal properties of crude plant extracts from ten medicinal plant species. Crude samples were extracted using the hot water ...

Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics. Some of these studies have resulted in the identification of novel compounds that act against these pathways and also demonstrate potent antifungal activity. However, considerable effort is...

AIMS To characterize and explore the potential in extracellular biosynthesis of silver nanoparticles (AgNPs) by Penicillium chrysogenum and Aspergillus oryzae and to investigate the antifungal effect of chemically vs biologically synthesized AgNPs comparing with conventional antifungal drugs against Trichophyton rubrum. METHODS AND RESULTS Chemically synthesized AgNPs (Chem-AgNPs) coated with...

In recent years, the use of antifungal drugs in human medicine has increased, especially with the advent of AIDS epidemic. Efforts have focused on the development of new, less toxic and more efficacious antifungal drugs with novel mechanism of action. The purpose of this study was to synthesize of some new benzimidazole, benzotriazole and aminothiazole derivatives and to evaluate their activity...

objective: in this study the susceptibility of candida albicans to inhibitory effect of polyphenols under varying time (24 and 48 hours) conditions were evaluated. materials and methods: green tea leaf polyphenols were extracted and analyzed by chromatography. among polyphenols, catechin showed stronger antifungal activity against c. albicans ptcc-5027. catechin's mic90 (the concentration of c...

OBJECTIVE Candida albicans biofilm is frequently found on artificial surfaces and the infections related to biofilm are difficult to eliminate, as they require the removal of artificial devices and treatment with antifungal drugs. Nowadays, fungal growth in biofilms is difficult to eradicate with conventional antifungal drugs such as fluconazole. Among chelating agents, disodium salt-Ethylene D...

BACKGROUND Candida species, as opportunistic organisms, can cause various clinical manifestations, ranging from mild cutaneous infections to systemic candidiasis in otherwise healthy individuals. Remarkably, the incidence and mortality rates of candidemia have significantly increased worldwide, even after advances in medical interventions and the development of novel antifungal drugs. OBJECTI...