The effect of drugs from the class of cardiac (methyldigoxin, verapamil, propranolol), antiepileptic (carbamazepine), sedative (diazepam) and antihistaminic (promethazine) drugs on Na,K-ATPase activity of plasma membranes was studied in rat brain synaptosomes. Methyldigoxin in a concentration of 0.1 mmol/l inhibits enzyme activity by 80 %. Verapamil, propranolol and promethazine in concentratio...

BACKGROUND This study evaluated the anti-allergic activity of corilagin and also postulates the possible mechanism of its action. MATERIAL AND METHODS Corilagin was given orally at dose of 10, 20, and 40 mg/kg/day. All the animals (guinea pigs, rats, and mice) were sensitized for allergy such as eosinophilia and leukocytosis induced by milk; degranulation of mast cell by compound 48/80; and pas...

To cite: Ferreira MB, Rocha SM, Maia JM, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2013-201200 DESCRIPTION A 77 -year-old man, with a history of arterial hypertension, hypercholesterolaemia and obesity, presented to our emergency department with acute swelling of the tongue. He was being treated with an ACE inhibitor and a statin for the past few yea...

The recorded reports of cutaneous eruptions due to the antihistaminic drugs have been few in number (1,2,3,4, 5, 6,7), but none of these has been truly urticarial in nature. McElin and Horton (1) in 1945 reported one instance of generalized pruritus, following thirty-eight intravenous injections of Benadryl hydrochloride in twenty-six patients. Epstein (2) reported two patients with atopic ecze...

The synthesis of a series of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-ami nes and the preliminary evaluation of their in vivo antihistamine activity are described. The title compounds were obtained starting from either 1, 4, 10, or 55 by different synthetic methods. Substitution on the phenyl nucleus of the benzimidazole ring (84-87) was achieved by two different approache...

PURPOSE In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. METHODS Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these prep...

Background: Overuse of antibiotics among the patients with upper respiratory tract infection (URTI) is a worldwide problem, leading to antimicrobial resistance. This study aimed evaluate appropriateness prescribing for infections in tertiary care teaching hospital. Methods: was cross-sectional, observational study. Data collected from outdoor adult who were clinically diagnosed have URTIs Gener...