ABSTRACT There has been an increasing interest in the chemistry of pyridazinone derivatives because of their biological significance. Pyridazinones have been reported to possess variety of biological activities like antidiabetic, anticancer, anti-AIDS, cardiovascular, antiinflammatory, anticonvulsant and cerebroprotective, analgesics, antidepressant, anticonvulsant, antiasthmatic, anti-HIV1, an...

Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 microg/ml. LPS-induced PGE2 production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significant...

Earthworm is widely used in Chinese traditional medicine. Previous studies on earthworm extracts have demonstrated its ability to improve haemostatic disorders[5] and stimulate wound healing[6]. In addition, higher concentrations of earthworm extracts are nontoxic and have excellent antiinflammatory and antipyretic properties[7]. Further researches have revealed the potential for using earthwor...

Statins inhibit the activity of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase in order to reduce cholesterol synthesis, leading to lower circulating concentrations of total cholesterol and low-density lipoprotein. In adults, statins have proven efficacy in reducing morbidity and mortality, and improving clinical outcomes, in those at risk of vascular disease. Beyond their lipid-lowering ef...

Drugs are a rare cause of pancreatitis. Whereas some drugs are well known to induce an attack of pancreatitis, some people may be more prone to develop pancreatitis because of personal susceptibility. We describe a recurrent case of acute pancreatitis after administration of several drugs in a patient with intestinal inflammatory bowel disease that needed to be treated with subsequent antiinfla...

Therapy of Inflammatory Bowel Disease Crohn’s disease and ulcerative colitis cause significant morbidity in the pediatric age group. The precise etiology of inflammatory bowel disease remains unknown; therefore, our therapeutic efforts continue to be directed toward controlling the symptoms. Current therapy for inflammatory bowel disease is focused on the use of steroids because of their anti-i...

Inhaled corticosteroids, such as beclomethasone dipropionate (BDP), are well recognized as the most effective antiinflammatory drugs currently available for the treatment of chronic asthma. Research to obtain effective and welltolerated asthma therapies has led to improvements in the delivery systems and formulations of inhaled corticosteroids and to the development of new steroid agents. This ...

Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are among the few agents known to be useful for the chemoprevention of neoplasia. Here, we show that the tumor suppressive effects of NSAIDs are not likely to be related to a reduction in prostaglandins but rather are due to the elevation of the prostaglandin precursor arachidonic acid (AA). NSAID treatment of...

The plant kingdom is a wide field to search for natural effective oral hypolipidemic agents that have slight or no side effects. The search for natural substances with hypolipidemic effects is therefore desirable, particularly in countries with a persistent incidence of hyperlipidemia and cardiovascular diseases. The consumption of synthetic drugs leads to hyperurecemia, diarrhoea, nausea, myos...