The extracts of 17 spices commonly used in Egypt as food condiments were screened for their antimicrobial activities against 7 standard microbial strains (S. aureus, B. subtilis, E. coli, P. aeruginosa, S. typhi, C. albicans and A. niger). Among the tested alcoholic extracts only 3 (clove, thyme and cinnamon) showed broad spectrum antimicrobial activities. Garlic juice too showed broad spectrum...

Commiphora molmol oleoresin (Family Burseraceae) is traditionally used for treatment of many ailments such as ulcers, abscesses and wounds. The aim of this study was to evaluate the antimicrobial and antioxidant activities of C. molmol extracts in vitro (essential oils and ethanol extract). The antimicrobial activities of extracts were evaluated by disc diffusion and micro-broth dilution assays...

New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mention...

The present study describes the phytochemical profile and antimicrobial activity of Matricaria chamomilla essential oil. The sample of essential oil was obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. A total 55 compounds were identified mainly including α-Pinene (22.11%), Camphene (10.8%), Sabinene (4%), Limonene(5.64%),1,8-Cineole(6.45%), Camphor (4%) a...

A new series of aryl-based synthetic mimics of antimicrobial peptides (SMAMPs) with antimicrobial activity and selectivity have been developed via systematic tuning of the aromatic groups and charge. The addition of a pendant aromatic group improved the antimicrobial activity against Gram-negative bacteria, while the addition of charge improved the selectivity. SMAMP 4 with six charges and a na...

Marine bacteria were isolated from seawater was collected from different coastal areas of the Tamilnadu Sea. The antimicrobial activities of these bacteria were investigated. Ethyl acetate extracts of marine bacterial fermentation were screened for antimicrobial activities using the method of agar diffusion. The results showed that 25 strains of the isolates have antimicrobial activity. The pro...

The effect of C-terminal amidation on the antimicrobial and hemolytic activities of antimicrobial peptides was studied using three cationic peptides which form amphiphilic α-helices when bound to membranes. The natural antimicrobial peptide PGLa, the designermade antibiotic MSI-103, and the cell-penetrating “model amphipathic peptide” (MAP) are all amidated in their original forms, and their bi...

A new heterocyclic Schiff base ligand bis(2-(pyridin-2-ylimino)phenyl)-4,4'-(diazene-1,2diyl)dibenzoate (BPPD, L) and its metal complexes with divalent transition metal ions viz., Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized through IR, NMR and elemental analysis. The ligand and its complexes have been screened for the antibacterial activities towards bacteria Staph...

Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense pept...

cr(iii), co(ii), ni(ii), cu(ii) and zn(ii) salts of 2-(4-nitrophenylaminocarbonyl)benzoic acid were characterized by physical, analytical and spectroscopic studies and checked for their  in-vitro antimicrobial activity against three bacterial strains, mycobacterium smegmatis (gram +ve), escherichia coli (gram -ve), pseudomonas aeuroginosa (gram -ve) and three fungal strains, nigrospora oryzae, ...