The use of antibiotic prophylaxis in patients predisposed to infective endocarditis (IE) who are undergoing oral surgery procedures is widely accepted. Because there have been no controlled clinical trials of antibiotic regimens for the prevention of endocarditis in humans, recommendations are based on the results of prophylaxis studies in animal models of endocarditis, in vitro susceptibility ...

The bacteriological consequences of giving long-term low-dose co-trimoxazole to children to prevent reinfection of the urinary tract were studied. Only six "break-through" infections occurred during 2637 child-months of prophylaxis. The children complied well with treatment. During prophylaxis the number of rectal coliform bacilli recovered was greatly and rapidly reduced, but at least 70% of t...

INTRODUCTION Healthcare-associated infections (HAIs) and antimicrobial resistance are well known major public health threats. The first goal of our study was to describe the prevalence of HAI, while the second goal was to describe the antibiotic consumption at our University Hospital, "P. Giaccone" in Palermo, Italy. METHODS A standardized methodology for a combined Point Prevalence Survey (P...

I read with interest the article by Sapian et al detailing their exhaustive and excellent epidemiological and clinical outcome research on the outbreak of melioidosis and leptospirosis among rescue workers during a rescue operation in the state of Pahang. The same episode resulting in the rare co-infection of melioidosis and leptopsirosis and its high mortality rate, was also similarly reported...