Abstract Introduction: Antithyroid drugs (ATDs) are widely used for the treatment of hyperthyroidism. Most side effects these medications mild and emerge within first months treatment. In contrast, antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is a severe adverse event whose occurrence increases with increasing time Vasculitis more frequently associated propylthiouracil tha...

Anti-neutrophil cytoplasmic auto antibodies are directed against antigens in the neutrophil granules. Their detection by the indirect immunofluorescence clearly divides them into two distinct types, namely c-ANCA (Classical antineutrophil cytoplasmic antibody) and the p-ANCA (Perinuclear antineutrophil cytoplasmic antibody). These antibodies have been found to be useful as non-invasive markers ...

ii ©2012 Aleeza Jane Roth ALL RIGHTS RESERVED iii ABSTRACT ALEEZA J ROTH: Characterization of antigenic determinants and their correlation with disease activity in ANCA glomerulonephritis (Under the direction of Dr. This dissertation focuses on the interaction of antineutrophil cytoplasmic autoantibodies (ANCA) and two of their target autoantigens, myeloperoxidase and lysosomal membrane protein...

Pulmonary-renal syndrome (PRS) is a combination of diffuse pulmonary hemorrhage and glomerulonephritis. Pulmonary-renal syndrome is not a single entity and is caused by a variety of conditions, including Goodpasturés syndrome associated with autoantibodies to the glomerular and alveolar basement membranes, various forms of primary systemic vasculitis associated with serum positivity for antineu...

<p>Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production newly formed antibodies. We report 21-year-old female past medical history Crohn’s disease controlled infliximab who presented to dermatology purpuric rash and crusted plaques her distal lower extremities. Biopsy lesion revealed ...