Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR is a very sensitive technique for free radical detection and characterization. It can be used to investigate very low concentrations of radicals provided that they are stable...

The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic protozoa via membrane transporters. However, no such diamidine transporter has been identified in mammalian cells. The goal of this study is to investigate whether these dicationic drugs are substrates for human organic cation transporters (hOCTs, solute carrier family ...

Anthelmintic discovery in the veterinary pharmaceutical industry has succeeded only through screening synthetic compounds and fermentation products against whole parasites in culture or in host animals. Following trends in the parent, and much larger, human pharmaceutical industry, many programs have been developed in the past 20 years to exploit mechanism-based screening strategies for the ide...

Nowadays, cattle breeding is a major economic issue throughout the world. However, gastrointestinal nematode parasitism remains sanitary threat on global scale, affecting animal health, farm productivity and well-being of farmers. Until recently, chemical anthelmintics occupied prominent place in fight against these parasites. But some them have developed resistance to antiparasitic drugs. The ...