Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight physiological regulatory mechanisms employed by rapidly proliferating cells. Due to severe side effects chemotherapeutic medications, plant chemicals their analogues are now explored frequently for treatment prevention colorectal (CRC), opening stage new phytotherapeutic strategi...

Sphingosine-1 kinase (SphK1) is one of the important enzymes phospholipids and its inhibition therapeutic strategies for different diseases. SphK1 over expression observed in types cancer indicating role tumor growth. In search effective inhibitors, a new series pyrazolylbenzimidazoles was synthesized evaluated as sphingosine kinase-1 inhibitors. order to evaluate binding affinities all compoun...

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1011-8934 eISSN 1598-6357 http://dx.doi.org/10.3346/jkms.2011.26.10.1397 • J Korean Me...

Fatty acid synthase (FASN) is highly expressed in breast carcinomas to support their continuous growth and proliferation, but has low expression level in normal tissues. Considerable interest has been developed in searching for novel FASN inhibitors as a therapeutic target for breast cancer. In present study, amentoflavone was isolated from Selaginella tamariscina, a traditional oriental medici...

Medicinal plants provide an inexhaustible source of anticancer drugs in terms of both variety and mechanism of action. Induction of apoptosis is the key success of plant products as anticancer agents. The present study was designed to determine the antiproliferative and apoptotic events of Moringa oleifera leaf extract (MLE) using human tumor (KB) cell line as a model system. KB cells were cult...

Chardonnay and Tinta Cao grape pomaces were generated by the winemaking process. The pomaces were extracted with 50% acetone and tested for antioxidant capacities using the oxygen radical absorbance capacity (ORAC) assay, 50 EC , and ABTS •+ scavenging capacity tests. Cytotoxicity and antiproliferative activities against Caco-2 and HT-29 human colon cancer cell lines were also analyzed. The qua...

BACKGROUND Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS To detect the most effective fraction, the antiproliferation...