INTRODUCTION Rheumatoid arthritis (RA) is known to be associated with a higher prevalence of antithyroid antibodies and autoimmune thyroid disease, but there have been few studies regarding the correlations between the presence of these antibodies and RA activity. OBJECTIVES The aim of this study was to analyze the relationship between antithyroid antibody titers and selected parameters of RA...

Experiments were performed to determine whether the absence of the enzyme sys tem tryptophan peroxidase (TPO) in transplanted hepatomas was associated with fac tors other than deletion of the apoenzymes, and whether changes in TPO activity and its adaptive response occurred during carcinogenesis with 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). No appreciable TPO activity was observed in tw...

BACKGROUND Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes. Although many theories have been suggested for its pathogenesis, the role of autoimmunity is the most popular one. The association of vitiligo with autoimmune thyroid diseases and the increased prevalence of autoantibodies including thyroid autoantibodies in vitiligo favor this role. Our objective was to...

Pregnancy has variable effects on thyroid hormone concentrations throughout pregnancy as well as being associated with goiter. The latter is largely preventable by ensuring optimal iodine intake of at least 200 microg/d. Immunologic changes in pregnancy include a so-called T(H)2 shift that reverts to T(H)1 status around birth or early in the postpartum period. Hyperthyroidism during gestation, ...

karyocyte colony formation. These data indicate that the IgG autoantibodies can specifically neutralize the in vitro biologic activity of TPO. The effectiveness of cyA in improving thrombocytopenia strongly suggests an immune-mediated pathogenetic mechanism in the patient. Although it is unclear that anti-TPO autoantibody is the sole cause of the thrombocytopenia, the recovery of serum TPO leve...

The relationship between mood disorders and abnormalities of the endocrine and immune systems have been described (Horning et al. 1998, Kanba et al. 1998). Thyroid abnormalities associated with lithium treatment have been widely reported, including goiter, hypothyroidism, hyperthyroidism, and autoimmune thyroiditis (Kibirige et al. 2013). The presence of antithyroid antibody titers in bipolar p...

Auto-antibodies (aAbs) to thyroid peroxidase (TPO) interact with a restricted immunodominant region (IDR) divided into two overlapping regions A and B. Among the five major regions structuring the IDR/B, regions 210-225, 353-363, 549-563, 713-720 and 766-775, region 353-363 constitutes an important anchor point for the binding of TPO-specific aAbs in sera from Hashimoto's and Graves' patients. ...

background:   objective: to investigate the effectiveness of levothyroxine in treatment of rpl in women with high auto-thyroid antibodies.   materials and methods: in this observational cross sectional study, 900 women who had a history of recurrent pregnancy loss were studied. all women with high anti-tpo antibody without any other problems entered in this study. levothyroxine was given to the...

BACKGROUND Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows ...

OBJECTIVE To study the prevalence of increased TSH level and its probable cause in children with Down's syndrome treated at Policlínica Antônio Cândido. METHODS The data were collected using medical records of 169 patients. Of these, 46 patients, whose TSH increased at some time during their follow-up, were re-evaluated. In these patients, TSH, free T4, total T4 and thyroid peroxidase autoant...