نتایج جستجو برای: antitubercular activity
تعداد نتایج: 1136222 فیلتر نتایج به سال:
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity...
Isoniazid (INH) is a key antitubercular agent, which exhibits poor chemical stability in the solid state associated with hydrazide group. Cocrystallization Gentisic Acid having antioxidant activity, may produce forms improved pharmaceutical properties. The complementary nature of functional groups isoniazid and chosen coformer resulted success for cocrystal formation. Cocrystal (INH-Gentisic ac...
A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious antitubercular activities could be observed (MIC > 10 g/mL). The results are in sharp contrast with the previously reported data.
An efficient one pot condensation of naphthols (1), 2,5-disubstituted indole-3-carboxaldehydes (2), and secondary amines (3) has been achieved using dichloromethane as a solvent, stirring at room temperature. Some of the new [(disubstituted amino)(5-substituted 2-phenyl-1H-indol-3-yl)methyl]naphthalene-ols (4) derivatives were prepared in good yields. The significant features of this method are...
World Health Organization considers Mycobacterium tuberculosis is the most dangerous chronic transmittable disease. Development of resistance by a common problem world Wide. To combat these problems there could be solution that we should search newer molecules with different mechanism action to fight against such diseases. A series some novel benzothiazole derivatives (I-X) have been synthesize...
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