نتایج جستجو برای: antitubercular agents
تعداد نتایج: 361077 فیلتر نتایج به سال:
98 patients with tuberculous meningitis were studied with a view to assessing the value of steroids as an adjuvant to antitubercular drugs. The patients were divided into three groups irrespective of the clinical stage of the disease. One group received antitubercular drugs alone, the second oral prednisolone, and the third intrathecal steroids, in addition to the antitubercular drugs. There wa...
isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. while compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. all the compounds were screened for their antitubercular and antimicrobial activities...
In Vitro Activities of the New Antitubercular Agents PA-824 and BTZ043 against Nocardia brasiliensis
TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions one of the major concerns for management TB. The current study has been conducted identifying causality assessment, severity as well preventability first-line anti-tubercular agents. All diagnosed patients tuberculosis attending and chest departmen...
BACKGROUND Rifampicin induces expression of the cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolizes efavirenz. The CYP2B6 516G>T polymorphism impairs efavirenz metabolism and occurs more commonly in Africans than in Caucasians. We explored the effect of rifampicin-based antitubercular therapy and the 516G>T polymorphism on efavirenz concentrations in HIV-infected patients in South Africa....
OBJECTIVES A novel and simple method to synthesize antitubercular-protein conjugate by solid phase synthesis was developed employing a carboxypolystyrene resin. The aim was to covalently bind a drug with antitubercular activity, isoniazid, to a biomacromolecule, gelatin, widely used in the pharmaceutical, cosmetic and food industry. METHODS Calorimetric and (1) H NMR analyses were performed t...
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