26 The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related 27 afferents and a strategic site for the modulation of the cough reflex. The similarities 28 between the characteristics of central processing of nociceptive and cough-related inputs 29 led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, 30 could also be involved in the ...

BACKGROUND Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with anti-inflammatory and bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms in...

Transient receptor potential vanilloid 1 (TRPV1) plays an integral role in modulating the cough reflex, and it is an attractive antitussive drug target. The purpose of this study was to characterize a TRPV1 antagonist, 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), against the guinea pig TRPV1 receptor in vitro followed by a...

Cough may be the presenting feature ofasthma in adults and children.12 Treatments for asthma, such as f stimulant drugs, are known to be effective in controlling the symptom.1 Ellul-Micaleff demonstrated the efficacy of oral terbutaline sulphate in a double blind, placebo controlled crossover study of 30 patients with chronic "allergic" cough.3 In whooping cough. inhaled salbutamol has been fou...

Cough may be the presenting feature ofasthma in adults and children.12 Treatments for asthma, such as f stimulant drugs, are known to be effective in controlling the symptom.1 Ellul-Micaleff demonstrated the efficacy of oral terbutaline sulphate in a double blind, placebo controlled crossover study of 30 patients with chronic "allergic" cough.3 In whooping cough. inhaled salbutamol has been fou...

background: the relaxant and anticholinergic (functional antagonism) effects, histamine h 1 inhibitory effect, and calcium channel blocking effect of nigella sativa have been demonstrated on guinea pig tracheal chains.  several therapeutic effects including anti-asthma and dyspnea have also been ascribed to the seeds of nigella sativa.   objective: to evaluate the antitussive effect of this pla...

The roots of Stemona tuberosa have been used as an antitussive and insecticide remedy for thousands of years. On the chemical investigation of the roots of S. tuberosa, two new tuberostemonine-type alkaloids, epoxy-tuberostemonol (1), and neotuberostemoenone (2), together with a known alkaloid, neotuberostemonine, were isolated and identified. The structures of new alkaloids were established on...