Dextromethorphan (DM) is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, which is widely used as an antitussive agent. DM also prevents neuronal damage and modulates pain sensation via noncompetitive antagonism of excitatory amino acids (EAAs). DM has been found to be useful in the treatment of pain in cancer patients and in the treatment of methotrexate-induced neurotoxicity....

Dextromethorphan (DEX) is an antitussive agent used in many cough and cold medications, and dextrorphan (DOR) is its metabolite. Owing to their similar structures, optimization of the condition for the chromatography approach, which is in common use for determination, is both demanding and time-consuming. This paper describes a methodology that combines excitation-emission matrix fluorescence s...

Croton grewioides Baill. popularly known as “canelinha” or “canelinha-de-cheiro” has been used for the treatment of influenza, antitussive, febrifuge and headache; however, study its phytochemical composition is limited. The aim this was to investigate effect extraction method seasonality through leaf extracts four accessions by fingerprint chromatograms aided principal component analysis analy...

Platycodin D is an active component isolated from Chinese herb Platycodonis radix with various pharmacological activities, such as antitussive, expectorant, anti-inflammatory, and analgesic effects. Interestingly, platycodin also exerts anticancer effects against several types of cancer. However, few studies on the anti-tumour urinary bladder cancer have been reported. In this study, we explore...

Verbascum species, the largest genus of the family Scrophulariaceae, have been used in traditional medicines for centuries in almost all parts of the world. In this paper, the usage, biological activities (antioxidant, anticholinesterase, antiinflammatory, antinociceptive, wound healing, cytotoxic, anticancer, antitumor, immunomodulatory, antimicrobial, antimalarial, anthelmintic, antiviral, an...

This invention is a healthful composition comprising a hot-water extract of the cultivated mycelia of Cordyceps sinensis. The healthful composition of the invention is an oral healthful composition which is highly safe and has excellent cardiotonic, hypotensive, antitussive and anti-fatigue effects. Inventors: Taketomo; Naoki (Tokyo, JP); Tsunoo; Akinobu (Tokyo, JP); Itoh; Hiroyuki (Kanagawa, J...

Experimental ischemia models have shown the antitussive dextromethorphan to be an N-methyl-D-aspartate antagonist with neuroprotective properties. We treated 10 patients with a history of recent stroke or transient ischemic attack with oral dextromethorphan (60 mg q.i.d.) for 3 weeks in a placebo-controlled, double-blind, crossover tolerance study. We documented no clinical evidence of toxicity...

Cough is a primitive reflex typically consisting of an initiating deep inspiration, glottal closure, and an explosive expiration accompanied by a sound. The flow characteristics of cough have been shown to differ between different pulmonary diseases. Cough sounds are generated at the larynx and in the lungs. Modern analysing techniques have also been applied in cough sound studies, and differen...

Cannabis has been demonstrated to have bronchodilator, anti-inflammatory, and antitussive activity in the airways, but information on the active cannabinoids, their receptors, and the mechanisms for these effects is limited. We compared the effects of Δ(9)-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabichromene, cannabidiolic acid, and tetrahydrocannabivarin on contractions of the guin...