Helicobacter pylori is an important risk factor for peptic ulcers. If infection withH pylori is cured, ulcers associated with H pylori do not recur. An H pylori “test and treat” strategy for patients with peptic ulcers having long term antisecretory treatment has been suggested, in the hope that eradicating H pylori would curtail the rising use of antiulcer drugs. 2 We describe the long term ef...

Ulcers are the most common form of GI disorder that is often caused by either inflammation or infection that certainly affected 10% of the population at risk. Among all types of ulcers, peptic ulcer is the more catastrophic one. This point made an exemption objective to conduct an investigation for antiulcer activity of alcoholic extract of Garuga pinnata leaves in rats. Acute gastric lesions i...

New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a beta-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated an...

The effect of 50 % ethanolic extract of Alectra parasitica var. Chirakutensis was assessed in different acute gastric ulcer models in rats. Alectra parasitica administered orally at dose levels of 50 – 200 mg/kg, twice daily for 3 days showed dose dependent ulcer protective effect 48.89 – 82.22% protection on aspirin -induced acute ulcers. Besides, Alectra parasitica reduced the ulcer index wit...

In the past two decades, increasing consumption of synthetic drugs and its associated side effects has led World Health Organization (WHO) to study the antioxidant activity of this plant. It also conducted an ethno botanical survey of endemic medicinal plants studying its uses by the rural populations in order to prevent and treat many current diseases (1). Achillea species such as Achillea mil...

The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studied. The extract (200 mg/kg and 400 mg/kg po) was administered to the overnight fasted rats, one hour prior to aspirin / alcohol / pyloric ligation challenge. The ulcer index, tis...