The mechanism(s) by which diets containing corn or coconut oil (31% of energy as fat) totally free of cholesterol or with 0.1% added cholesterol by weight (0.3 mg/kcal) affect plasma high density lipoprotein cholesterol (HDL-C), apoprotein (apo) A-I levels, apo A-I kinetics, and hepatic apo A-I mRNA concentrations were investigated in 26 cebus monkeys. Coconut oil-fed monkeys had elevated level...

Apolipoprotein E (apo E) plays a role in the regulation of the lipid metabolism of humans. Apo E, 229 amino acid polypeptide, is classified into three major isoform (E2, E3, E4) according to the differences of amino acid in position 112 and 158. In the normal population apo E3 isoform is most prevalent and apo E2 or E4 is frequently associated with hyperlipoproteinemia. To find out the frequenc...

Apolipoprotein E (apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major apo E isoforms are encoded by three common alleles at the APO E locus. The E2 allele is associated with lower and the E4 allele with higher total plasma cholesterol and LDL cholesterol levels compared with the E3 allele. Available data generally indicate...

Fresh plasma from control (C) and hyperchotesterolemlc (HC) cynomolgus monkeys was analyzed by agarose electrophoresls-lmmunoblotting with antibody to cynomolgus monkey apolipoprotein (apo) A-l. Two bands were evident on the autoradiogram: an a-migrating band (high density llpoproteln) and a /3-mlgrating band that comlgrated exactly with cynomolgus monkey low density llpoproteln (LDL). The pres...

background: preliminary clinical trials showed that ginger improved lipid profile in type 2 diabetes patients (t2d). this trial was carried out to determine the effect of ginger on blood lipid and lipoproteins in t2d. methods: this is a randomized, double-blind, placebo-controlled trial on 88 t2d conducted in. the patients were randomly divided into two groups of ginger (gg) and placebo (pg), t...

b a ckground:  to compare the oxidative stress (os) factors in obese and non- obese subjects with type 2 diabetes (t2d) and to evaluate the interaction between the apolipoprotein a-ii (apo a-ii) - 265t > c polymorphism and body mass index (bmi) on os factors. m ethods : in this comparative cross-sectional study, 21 diabetes centers in tehran, iran were studied. 180 patients with t2d were divide...

Biosynthesis of locust apolipophorin-111 (apo-111) was studied in vitro. Gel electrophoresis and immunoblotting analyses of the locust hemolymph demonstrated that apo-111 first appears in the hemolymph on the day 3 of the adult stage after the final molt and its hemolymph concentration increases thereafter. When incubated in vitro in a medium containing radioactive amino acid, the fat body cell...

Rat apolipoproteins (apo-) A-IV and A-I share many structural similarities, the most notable of which is a domain of repeated docosapeptides with amphipathic helical potential. Although the genes for apo-A-IV and apo-A-I probably diverged from a common ancestor, these proteins seem to have developed different functions in their evolution. In the present study, cloned cDNAs were used to characte...