Abstract Background Preeclampsia (PE) is a pregnancy related disease that affects about 5% of pregnancies. Death receptor 3 (DR3) expression significantly elevated in both placental tissue and plasma PE patients. However, whether DR3 was involved trophoblasts pathogenesis are not well elucidated. Objective Our research designed to illustrate the biological roles trophoblasts, as explain its rel...

background: the anti-cancer effects of honey bee venom (bv) and chrysin might open a new window for treatment of chemo-resistant cancers. this study was designed to evaluate cytotoxic and pro-apoptotic effects of bv and chrysin on a2780cp cistplatin- resistant human ovarian cancer cells. methods: as per the study objectives, a2780cp cells were categorized to 4 groups: 3 experiment groups (treat...

objective(s): protein kinase c (pkcα) is involved in modulating articular chondrocytes apoptosis induced by nitric oxide (no). hyaluronic acid (ha) inhibits nitric oxide-induced apoptosis of articular chondrocytes by protecting pkcα, but the mechanism remains unclear. the present study was performed to investigate the effects and mechanisms of pkcα regulate protective effect of hyaluronic acid....

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cells are usually insensitive TRAIL so reducing this drug resistance may improve treatment of cancer. In study, we Cell Counting Kit-8 (CCK-8) 5-ethynyl-2′-deoxyuridine (EdU) experiments determine effects 5-f...

understanding the mechanism of tumor resistance is critical for cancer therapy. in this study, we investigated the effect of carcinoembryonic antigen (cea) overexpression on uv-and 5-fluorouracil (5-fu)-induced apoptosis and autophagy in colorectal cancer cells. we used histone deacetylase (hdac) inhibitor, nab and dna demethylating agent, 5- azacytidine (5-aza) to induce cea expression in ht29...

background and aims: epigallocatechin-3-gallate (egcg) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which egcg induces apoptosis remains unknown. the aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of egcg on pc3 human prostate cancer ...

Multiple myeloma (MM) is incurable cancer in the blood system. Magnolol an effective component against various cancers. This study tried to investigate effect and mechanism of magnolol on MM via regulating miR-129. Human normal plasma cells (nPCs) U266 LP1 were used this study, accompanied by treatment magnolol. The miR-129 inhibitor was transfected into during experiments. Cell viability detec...

Introduction: The knowledge about the biology of obesity and apoptosis induction adipose-derived stem cells (ADSCs) may support in development new therapies. Objective: present research aimed to investigate toxicogenic effect all-trans retinoic acid (ATRA) as well its influence adipogenic differentiation expression genes related DNA damage, cell cycle thermogenesis. Methodology: Cell cultures h...

Thymus capitatus is a plant grows in Mediterranean area and some Arab countries such as Saudi Arabia. It possesses numerous medicinal values. Its common name Zaatar it belongs to family Lamiaceae leaves stem were collected from Hail region, Then both extracted with ethanol. This study was performed evaluate cytotoxic activity of ethanolic extract details. Doxorubicin used standard the relevant ...