Uncontrolled apoptosis has been associated with several pulmonary disorders; however, the molecular mechanism underlying this process and the fate of apoptotic cells in vivo are unclear. Here we show that direct administration of apoptotic cells to the lungs of rats caused pulmonary inflammation and fibrosis, as indicated by emigration of inflammatory cells to the air spaces, TNF-alpha immunore...

The proto-oncoprotein c-Cbl controls several down-regulation signals leading to degradation of tyrosine-kinase receptors (TKR) [1-3] or endocytic trafficking [1,4,5]. It interacts with numerous signalling proteins through their Src homology-2 or -3 (SH2 or SH3) domains [6,7]. Several groups, including ours, have reported an association between down-regulation of apoptosis and c-Cbl. First, onco...

objective(s):the use of doxorubicin (dox) is limited by its dose-dependent cardio toxicity in which reactive oxygen species (ros) play an important role in the pathological process. the aim of this study was to evaluate the protective effect of three medicinal plants, nigella sativa (n), glycyrrhiza glabra (g) and zingiber officinale (z), and their combination (ngz), against dox-induced apoptos...

the purpose of the present study is to investigate the cytotoxicity/apoptotic effect of 2-chloro-2′-deoxyadenosine, cladribine, (2-cda) in the human breast cancer cell line, mda-mb468 (estrogen receptor negative, er−). mtt [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h tetrazolium bromide] assay, annexin v-fluorescein/pi and hoechst 33258 staining were used to detect cytotoxicity and cell apopto...

Poncirin, a natural bitter flavanone glycoside abundantly present in many species of citrus fruits, has various biological benefits such as anti-oxidant, anti-microbial, anti-inflammatory and anti-cancer activities. The anti-cancer mechanism of Poncirin remains elusive to date. In this study, we investigated the anti-cancer effects of Poncirin in AGS human gastric cancer cells (gastric adenocar...

It is proposed that both preand postnatal as well as genetically determined abnormalities of the apoptotic processes are among factors responsible for the development of schizophrenia. The ultimate vulnerability of cells to diverse apoptotic stimuli is determined by the relative ratio of various pro-apoptotic and anti-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family proteins among whic...

Pemphigus vulgaris (PV), a severe mucocutaneous blistering disease, results from autoantibody-mediated destabilization of epidermal cell-cell adhesion. A functional risk variant at the ST18 locus was found to promote expression. Increased expression aggravate deleterious effect PV autoantibodies in part through induction p53-mediated pro-apoptotic pathways. Global RNA sequencing human keratinoc...

This study was an attempt to determine the effect of a selected anthracycline derivative, WP903, on apoptotic processes in human melanoma cells depending on intracellular concentrations of the compound, and to evaluate the significance of apoptosis induction for the cytotoxic effect of anthracycline antibiotics. It was found that the WP903, contrary to ADR (adriamycin) is a strong inducer of ap...

background and objective: in neurodegenerative disorders, oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages that lead to apoptosis. pro-apoptotic and anti-apoptotic gene expressions were changed during cell differentiation that affect cell viability and differentiation. this study was conducted to determine the effects of hydrogen peroxi...

Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...