Promotion of appropriate and safe drugs in children is the need of the hour globally. Pediatric population by itself is a spectrum of different physiologies with significant variation in pharmacodynamics and pharmacokinetics. Unfortunately, 50-90% of drugs used in children today have never been actually studied in this population, and the results of drug studies done in adults are often extrapo...

It was with much interest that we read the letter of Novikov et al on testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with ANCA-associated vasculitides (AAV) and other diseases. In their letter, the authors (1) share their experience with direct testing for proteinase-3 (PR3) ANCA and myeloperoxidase (MPO) ANCA and (2) raise some important issues regarding interpretation o...

Self-plagiarism requires clear definition within an environment that places integrity at the heart of the research enterprise. This paper explores the whole notion of self-plagiarism by academics and distinguishes between appropriate and inappropriate textual re-use in academic publications, while considering research on other forms of plagiarism such as student plagiarism. Based on the practic...

OBJECTIVES To emphasize the magnitude and burden of migraine, the need for greater use of migraine-preventive medications in patients who could most benefit from them, and the role that pharmacists can play in migraine prevention. DATA SOURCES PubMed and Medline-based literature searches were conducted to determine the need for migraine-preventive medications, the treatment of migraine, and h...

For the first 30 years after carotid endarterectomy was first developed, anecdotal evidence was used to identify patients with internal carotid artery disease for whom this procedure would be appropriate. More recently, the appropriateness of carotid endarterectomy for symptomatic patients and asymptomatic subjects has emerged from 7 randomized trials. Risk of stroke and benefit from the proced...

Teleradiology involves much more than merely transmitting images and information between two points: teleradiology consists of sharing knowledge and working together in a network. It facilitates rapid access to radiological reports and second opinions, remote consulting among physicians, improved patient care, access to complex tools for postprocessing and computer-aided diagnosis, support for ...

The many criticisms of null hypothesis testing suggest when it is not useful and what is should not be used for. This article explores when and why its use is appropriate. Null hypothesis testing is insufficient when size of effect is important, but it is ideal for testing ordinal claims relating the order of conditions, which are common in psychology. Null hypothesis testing also is insufficie...

There has been a significant increase in cardiac radionuclide imaging over the past decade, leading to a corresponding increase in scrutiny from Federal and private health plans questioning the necessity of these tests. In response to efforts by third-party payers to limit all types of cardiovascular imaging studies, the American College of Cardiology Foundation, in conjunction with other profe...