possibly because they associate with tissue-specific ef-fectors and negative regulators, but can also exhibit a Canada degree of functional redundancy. Multiple Pathways from Receptors to the Nucleus There are several pathways through which pTyr signals A significant issue in signal transduction is whether indi-can be relayed to the nucleus (Figure 1). STAT proteins vidual biochemical pathways ...

Heme proteins are among the most abundant and important metalloproteins, exerting diverse biological functions including oxygen transport, small molecule sensing, selective C-H bond activation, nitrite reduction, and electron transfer. Rational heme protein designs focus on the modification of the heme-binding active site and the heme group, protein hybridization and domain swapping, and de nov...