Antibiotics such as fluoroquinolones (FQLs) are commonly used to treat ocular infections but are also known to cause dermal melanocyte toxicity. The release of dispersed pigments from the iris into the aqueous humor has been considered a possible ocular side effect of the systemic administration of FQLs such as Moxifloxacin, and this condition is known as bilateral acute iris transillumination ...

Numerous investigators* have utilized pentobarbital Na as an anesthetic in monkeys for experiments on aqueous humor dynamics. Eakins showed that pentobarbital Na probably decreased the rate of aqueous humor formation in the cat eye. To our knowledge, similar inhibitory responses, if any, on aqueous humor formation have never been studied in monkeys. This report was conducted to determine if pen...

PURPOSE A previous study by the authors has shown that recombinant myocilin purified from a prokaryotic expression system increases outflow resistance in cultured human anterior segments. The present study was performed to determine whether full-length myocilin purified from a human trabecular meshwork cell expression system alters outflow resistance after infusion into human anterior segments....

Numerous investigators* have utilized pentobarbital Na as an anesthetic in monkeys for experiments on aqueous humor dynamics. Eakins showed that pentobarbital Na probably decreased the rate of aqueous humor formation in the cat eye. To our knowledge, similar inhibitory responses, if any, on aqueous humor formation have never been studied in monkeys. This report was conducted to determine if pen...

Purpose. To evaluate aqueous humor MMP-9 levels in alkali-burned rabbit cornea following KPr implantation and their roles in RPMs formation. Methods. Left eyes of 36 rabbits received a deep corneal alkali wound. 12 corneas were implanted with KPro and the other 24 control corneas were either penetrating keratoplasty or left without keratoplasty. Aqueous humor MMP-9 and TIMP-1 levels were determ...

PURPOSE To ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in non-diabetic patients following uncomplicated phacoemulsification cataract surgery. METHODS Undiluted aqueous humor samples were obtained from 288 consecutive non-diabetic patients (288 eyes; 132 men and 156 women) who underwent cataract surgery. Macular edema was defined as an increase in the foveal...

Matrix metalloproteinases (MMPs) are a family of extracellular endoproteinases that are receiving considerable attention from biologists, clinicians, and the pharmaceutical industry. MMPs play a major role in normal development, reproduction, and tissue remodeling. In addition, these molecules are involved in a number of pathogenic processes including cancer, arthritis, angiogenesis, and wound ...

Richard F. Figure 1 shows a human eye without its aqueous circulation. The cornea is thickened, the anterior chamber is absent, the iris is partly atrophic, and the lens is cataractous. The picture serves as a reminder of the dependency of the health of the eye on the continuous supply of aqueous humor that circulates through its chambers. It is surprising that it was not known until recently t...

OBJECTIVE Pigment epithelium-derived factor (PEDF) is an antiangiogenic/neurotrophic dual functional factor, and recently it was also shown to mediate antioxidative and anti-inflammatory action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with idiopathic acute anterior uveitis (IAAU). METHODS A comparative control study. Aqueous humor was collecte...

Glucocorticoids have long been implicated in the etiology of primary open-angle glaucoma (POAG) and cataract. Cortisol metabolites have biologic activity and may affect aqueous humor dynamics. This study was done to determine whether these metabolites are found in human aqueous humor and can be produced by ocular tissues. Radioimmunoassays (RIA) were developed for 5 alpha-dihydrocortisol (5 alp...